Swertia cincta Burkill alleviates LPS/D-GalN-induced acute liver failure by modulating apoptosis and oxidative stress signaling pathways

Burkill is widely distributed along the southwestern region of China. It is known as "Dida" in Tibetan and "Qingyedan" in Chinese medicine. It was used in folk medicine to treat hepatitis and other liver diseases. To understand how Burkill extract (ESC) protects against acute liv...

Full description

Saved in:
Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2023-06, Vol.15 (12), p.5887-5916
Main Authors: Wu, Xinyan, Zheng, Xiaomei, Wen, Qiqi, Zhang, Yang, Tang, Huaqiao, Zhao, Ling, Shi, Fei, Li, Yinglun, Yin, Zhongqiong, Zou, Yuanfeng, Song, Xu, Li, Lixia, Zhao, Xinghong, Ye, Gang
Format: Article
Language:English
Subjects:
Apoptosis
ErbB Receptors - metabolism
Humans
Lipopolysaccharides - pharmacology
Liver Failure, Acute - chemically induced
Liver Failure, Acute - drug therapy
Oxidative Stress
Phosphatidylinositol 3-Kinases - metabolism
Proto-Oncogene Proteins c-akt - metabolism
Research Paper
Signal Transduction
Swertia - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Burkill is widely distributed along the southwestern region of China. It is known as "Dida" in Tibetan and "Qingyedan" in Chinese medicine. It was used in folk medicine to treat hepatitis and other liver diseases. To understand how Burkill extract (ESC) protects against acute liver failure (ALF), firstly, the active ingredients of ESC were identified using liquid chromatography-mass spectrometry (LC-MS), and further screening. Next, network pharmacology analyses were performed to identify the core targets of ESC against ALF and further determine the potential mechanisms. Finally, experiments as well as experiments were conducted for further validation. The results revealed that 72 potential targets of ESC were identified using target prediction. The core targets were ALB, ERBB2, AKT1, MMP9, EGFR, PTPRC, MTOR, ESR1, VEGFA, and HIF1A. Next, KEGG pathway analysis showed that EGFR and PI3K-AKT signaling pathways could have been involved in ESC against ALF. ESC exhibits hepatic protective functions via anti-inflammatory, antioxidant, and anti-apoptotic effects. Therefore, the EGFR-ERK, PI3K-AKT, and NRF2/HO-1 signaling pathways could participate in the therapeutic effects of ESC on ALF.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.204848