Effects of dutasteride and tamsulosin on penile morphology in a rodent model

ABSTRACT Purpose To evaluate the penile morphology after the isolated and combined administration of dutasteride and tamsulosin in a rodent model. Materials and Methods Forty male rats were assigned into the following groups: Control group (C, receiving distilled water, n=10); Dutasteride group (D,...

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Bibliographic Details
Published in:International Brazilian Journal of Urology 2023-05, Vol.49 (3), p.320-333
Main Authors: Da Silva, Marcello H. A., Costa, Waldemar S., Sampaio, Francisco J. B., Souza, Diogo B. de
Format: Article
Language:English
Subjects:
Dutasteride
Erectile Dysfunction
Original
Prostatic Hyperplasia
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Summary:ABSTRACT Purpose To evaluate the penile morphology after the isolated and combined administration of dutasteride and tamsulosin in a rodent model. Materials and Methods Forty male rats were assigned into the following groups: Control group (C, receiving distilled water, n=10); Dutasteride group (D, receiving 0.5 mg/Kg/day of dutasteride, n=10); Tamsulosin group (T, receiving 0.4 mg/Kg/day of tamsulosin, n=10); and Dutasteride associated with Tamsulosin group (DT, receiving both drugs n = 10). All drugs were administered via oral gavage. After 40 days, the animals were submitted to euthanasia and their penises were collected for histomorphometric analyses. Data were compared using one-way ANOVA followed by Bonferroni’s post-test, considering p
ISSN:1677-5538
1677-6119
DOI:10.1590/s1677-5538.ibju.2022.0583