The ORIGINS Project Biobank: A Collaborative Bio Resource for Investigating the Developmental Origins of Health and Disease

Early onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental...

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2023-07, Vol.20 (13), p.6297
Main Authors: D'Vaz, Nina, Kidd, Courtney, Miller, Sarah, Amin, Minda, Davis, Jacqueline A, Talati, Zenobia, Silva, Desiree T, Prescott, Susan L
Format: Article
Language:English
Subjects:
Allergies
Amniotic fluid
Biobanks
Blood
Children
Clinical trials
Cohort analysis
Collaboration
Colostrum
Comparative studies
Cord blood
COVID-19
Data collection
Disease prevention
Ethics
Health risks
Hospitals
House dust
Informed consent
Meconium
Medical research
Metabolism
Origins
Pandemics
Placenta
Protocol
Research design
Saliva
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Early onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections. ORGINS is a prospective community birth cohort aiming to enrol 10,000 pregnant people and follow each family until the children reach 5 years of age. A key objective is to generate a comprehensive biorepository on a sub-group of 4000 families invited to contribute blood, saliva, buccal cells, urine, stool, hair, house dust, cord blood, placenta, amniotic fluid, meconium, breastmilk, and colostrum over eight timepoints spanning the antenatal period and early childhood. Uniquely, ORIGINS includes a series of nested sub-projects, including interventions and clinical trials addressing different aspects of health. While this adds complexity as the project expands, it provides the opportunity for comparative studies. This research design promotes a multidisciplinary, multisystem approach to biological sample collection, analysis, and data sharing to ensure more integrated perspectives and solutions. This paper details the evolving protocol of our collaborative biobanking concept. Further, we outline our future visions for local, national, and ultimately international, comparative, and collaborative opportunities to advance our understanding of early onset NCDs and the opportunities to improve health outcomes for future generations.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph20136297