Soft Tissue Ewing Sarcoma Cell Drug Resistance Revisited: A Systems Biology Approach

Ewing sarcoma is a rare type of cancer that develops in the bones and soft tissues. Drug therapy represents an extensively used modality for the treatment of sarcomas. However, cancer cells tend to develop resistance to antineoplastic agents, thereby posing a major barrier in treatment effectiveness...

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2023-07, Vol.20 (13), p.6288
Main Authors: Asfa, Seyedehsadaf, Toy, Halil Ibrahim, Arshinchi Bonab, Reza, Chrousos, George P, Pavlopoulou, Athanasia, Geronikolou, Styliani A
Format: Article
Language:English
Subjects:
Autonomic nervous system
Biomarkers
Bones
Cancer therapies
Chemoresistance
Chemotherapy
Datasets
DNA methylation
Drug resistance
Drug therapy
Epigenetics
Ewing's sarcoma
Ewings sarcoma
Gene expression
Gene set enrichment analysis
Genes
Genomes
Kinases
Medical prognosis
MicroRNAs
Molecular modelling
Non-coding RNA
Protein interaction
Proteins
Sarcoma
Soft tissues
Transcriptomics
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ewing sarcoma is a rare type of cancer that develops in the bones and soft tissues. Drug therapy represents an extensively used modality for the treatment of sarcomas. However, cancer cells tend to develop resistance to antineoplastic agents, thereby posing a major barrier in treatment effectiveness. Thus, there is a need to uncover the molecular mechanisms underlying chemoresistance in sarcomas and, hence, to enhance the anticancer treatment outcome. In this study, a differential gene expression analysis was conducted on high-throughput transcriptomic data of chemoresistant versus chemoresponsive Ewing sarcoma cells. By applying functional enrichment analysis and protein-protein interactions on the differentially expressed genes and their corresponding products, we uncovered genes with a hub role in drug resistance. Granted that non-coding RNA epigenetic regulators play a pivotal role in chemotherapy by targeting genes associated with drug response, we investigated the non-coding RNA molecules that potentially regulate the expression of the detected chemoresistance genes. Of particular importance, some chemoresistance-relevant genes were associated with the autonomic nervous system, suggesting the involvement of the latter in the drug response. The findings of this study could be taken into consideration in the clinical setting for the accurate assessment of drug response in sarcoma patients and the application of tailored therapeutic strategies.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph20136288