Cytokeratin 19 (CK19) expression by thyroid neoplasms in a Nigerian tertiary health centre

despite the observed appreciable sensitivity and specificity of the use of CK19 in predicting thyroid malignancies, there is still a paucity of information about its uses in Nigeria. Current information across the world is also scarce. This study was to review the histopathological diagnosis of thyr...

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Bibliographic Details
Published in:The Pan African medical journal 2023, Vol.44, p.176-176
Main Authors: Idowu, Soremekun Ademola, Olaniyi, Olaofe Olaejirinde, Oluwole, Komolafe Akinwumi
Format: Article
Language:English
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Summary:despite the observed appreciable sensitivity and specificity of the use of CK19 in predicting thyroid malignancies, there is still a paucity of information about its uses in Nigeria. Current information across the world is also scarce. This study was to review the histopathological diagnosis of thyroid neoplasms seen in Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile Ife, using cytokeratin 19 immunohistochemical marker. a retrospective study of fifty-six cases of thyroid neoplasm seen over a period of twenty years was conducted. The tissue samples were subjected to immunohistochemical staining for CK19 using monoclonal antibodies. The expression of the markers on the various thyroid neoplasms was assessed histologically. the expression of CK19 was significantly higher in malignant thyroid neoplasms compared to benign neoplasms (p
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2023.44.176.37751