Higher PAPP-A Values in Pregnant Women Complicated with Preeclampsia Than with Gestational Hypertension

The purpose of this study is to compare the levels of maternal serum pregnancy–associated plasma protein-A at the first trimester in pregnancies complicated by impaired placental diseases, such as preeclampsia (PE), intrauterine fetal growth restriction (IUGR), and gestational hypertension (GH), wit...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2023-08, Vol.30 (8), p.2503-2511
Main Authors: Uriel, Montserrat, Romero Infante, Ximena Carolina, Rincón Franco, Sara, Ibáñez Pinilla, Edgar Antonio, Rojas, Nydia Alexandra
Format: Article
Language:English
Subjects:
Biomarkers
Embryology
Female
Fetal Growth Retardation - diagnosis
Humans
Hypertension, Pregnancy-Induced - diagnosis
Infant, Newborn
Maternal Fetal Medicine/Biology: Original
Maternal Fetal Medicine/Biology: Original Article
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Placenta - metabolism
Placenta Diseases
Pre-Eclampsia
Pregnancy
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A - metabolism
Pregnant Women
Prospective Studies
Reproductive Medicine
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Summary:The purpose of this study is to compare the levels of maternal serum pregnancy–associated plasma protein-A at the first trimester in pregnancies complicated by impaired placental diseases, such as preeclampsia (PE), intrauterine fetal growth restriction (IUGR), and gestational hypertension (GH), with those in pregnancies without the development of any of these outcomes to expand the knowledge of how this protein behaves in the different impaired placental diseases. This current work is an observational study based on a prospective cohort. Pregnancy-associated plasma protein-A was measured in 422 patients who had completed maternal-perinatal outcomes. Comparisons of pregnancy characteristics and the biomarker between outcome groups (PE, IUGR, gestational hypertension, and not impaired placental outcomes) were analyzed. PAPP-A MoM in the IUGR (0.8 IQR: 0.6–0.9) and GH groups (0.5 IQR: 0.3–1.4) compared to the PE group (1.06 IQR: 0.66–1.52) was significantly lower ( p  
ISSN:1933-7191
1933-7205
DOI:10.1007/s43032-023-01176-1