In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution

To assess the in vitro and in situ effect of experimental combined fluoride and calcium nanocomposite solutions on dental caries prevention. Nanocompound mesoporous silica (MS) with calcium (Ca) and sodium fluoride (NaF) - (MSCaNaF); MS with NaF (MSNaF), NaF solution (positive control), and deionize...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian dental journal 2023-06, Vol.34 (3), p.119-128
Main Authors: Leite, Karla Lorene de França, Martins, Mariana Leonel, Dias, Millene de Oliveira, Tavares, Fernanda Oliveira Miranda, Justino, Isabella Barbosa dos Santos, Cabral, Lúcio Mendes, Neves, Aline de Almeida, Cavalcanti, Yuri Wanderley, Maia, Lucianne Cople
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c3080-636ee6c5378890fc11264336c4de86036e8273fb8d33123fe79f3c654286aaf33
container_end_page 128
container_issue 3
container_start_page 119
container_title Brazilian dental journal
container_volume 34
creator Leite, Karla Lorene de França
Martins, Mariana Leonel
Dias, Millene de Oliveira
Tavares, Fernanda Oliveira Miranda
Justino, Isabella Barbosa dos Santos
Cabral, Lúcio Mendes
Neves, Aline de Almeida
Cavalcanti, Yuri Wanderley
Maia, Lucianne Cople
description To assess the in vitro and in situ effect of experimental combined fluoride and calcium nanocomposite solutions on dental caries prevention. Nanocompound mesoporous silica (MS) with calcium (Ca) and sodium fluoride (NaF) - (MSCaNaF); MS with NaF (MSNaF), NaF solution (positive control), and deionized water (negative control - CG) were studied. The specimens (n=130) were submitted in vitro to a multispecies biofilm in the presence of 2% sucrose. After 24 h and 48 h, the culture medium pH, the percent of surface mineral loss (%SML), and lesion depth (ΔZ) were analyzed. In the in situ study, 10 volunteers participated in four phases of 7-days each. The products were applied on the specimens (n=240) before 20% sucrose solution drips. The polysaccharides (SEPS and IEPS), %SML and roughness (Sa) were evaluated. There was an in vitro decrease in pH values in 24h and 48h, compared to baseline. The MSCaNaF and MSNaF groups obtained lower values of %SML and ΔZ (p < 0.05) than CG and NaF after 24h and were similar to NaF after 48h (p0.05), while NaF was similar to CG (p>0.05). After 48h, the MSCaNaF and MSNaF reduced the %SML (p0.05). Regarding Sa, MSCaNaF was better than NaF for both periods (p
doi_str_mv 10.1590/0103-6440202305460
format article
fullrecord <record><control><sourceid>pubmedcentral_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10355272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_10355272</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3080-636ee6c5378890fc11264336c4de86036e8273fb8d33123fe79f3c654286aaf33</originalsourceid><addsrcrecordid>eNpVkc1OwzAQhC0EoqXwApz8AgHb6zjJCaGKn0qVuMA5cp01GKV25PxQ3h5DUaWe9jAzn0Y7hFxzdsPzit0yziBTUjLBBLBcKnZC5rxkKpOFYqdkfjDMyEXff7JklFCdkxkUUqmcV3OyW3k6uSEGqn1Dnae9G0ZqdHTYZ13ECf3gJqRoLZqBBks19fhFTdhunMeG2nYM0TX4lze6NW7cUtx1GN02ZXVLvfYh2buQ0Ej70I6DC_6SnFnd9nj1fxfk7fHhdfmcrV-eVsv7dWaAlSxToBCVyaEoy4pZw7lQEkAZ2WCpWFJLUYDdlA0AF2CxqCwYlUtRKq0twILc7bnduNliY1KnqNu6S_V0_K6DdvWx4t1H_R6mOv0uz0UhEkHsCSaGvo9oD2HO6t8h6t8_10dDwA_iI3v7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution</title><source>SciELO Brazil</source><source>PubMed Central</source><creator>Leite, Karla Lorene de França ; Martins, Mariana Leonel ; Dias, Millene de Oliveira ; Tavares, Fernanda Oliveira Miranda ; Justino, Isabella Barbosa dos Santos ; Cabral, Lúcio Mendes ; Neves, Aline de Almeida ; Cavalcanti, Yuri Wanderley ; Maia, Lucianne Cople</creator><creatorcontrib>Leite, Karla Lorene de França ; Martins, Mariana Leonel ; Dias, Millene de Oliveira ; Tavares, Fernanda Oliveira Miranda ; Justino, Isabella Barbosa dos Santos ; Cabral, Lúcio Mendes ; Neves, Aline de Almeida ; Cavalcanti, Yuri Wanderley ; Maia, Lucianne Cople</creatorcontrib><description>To assess the in vitro and in situ effect of experimental combined fluoride and calcium nanocomposite solutions on dental caries prevention. Nanocompound mesoporous silica (MS) with calcium (Ca) and sodium fluoride (NaF) - (MSCaNaF); MS with NaF (MSNaF), NaF solution (positive control), and deionized water (negative control - CG) were studied. The specimens (n=130) were submitted in vitro to a multispecies biofilm in the presence of 2% sucrose. After 24 h and 48 h, the culture medium pH, the percent of surface mineral loss (%SML), and lesion depth (ΔZ) were analyzed. In the in situ study, 10 volunteers participated in four phases of 7-days each. The products were applied on the specimens (n=240) before 20% sucrose solution drips. The polysaccharides (SEPS and IEPS), %SML and roughness (Sa) were evaluated. There was an in vitro decrease in pH values in 24h and 48h, compared to baseline. The MSCaNaF and MSNaF groups obtained lower values of %SML and ΔZ (p &lt; 0.05) than CG and NaF after 24h and were similar to NaF after 48h (p&lt;0.05). In situ results showed similar SEPS and IEPS among all groups after 48h. An after 7-days, the nanocomposites had similar values (p&gt;0.05), while NaF was similar to CG (p&gt;0.05). After 48h, the MSCaNaF and MSNaF reduced the %SML (p&lt;0.05). After 7-days, both experimental nanocomposites were similar to NaF (p&gt;0.05). Regarding Sa, MSCaNaF was better than NaF for both periods (p&lt;0.05). The nanocomposites controlled the in vitro and in situ enamel demineralization, mainly in the initial periods.</description><identifier>ISSN: 0103-6440</identifier><identifier>EISSN: 1806-4760</identifier><identifier>DOI: 10.1590/0103-6440202305460</identifier><identifier>PMID: 37466519</identifier><language>eng</language><publisher>Fundação Odontológica de Ribeirão Preto</publisher><ispartof>Brazilian dental journal, 2023-06, Vol.34 (3), p.119-128</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3080-636ee6c5378890fc11264336c4de86036e8273fb8d33123fe79f3c654286aaf33</cites><orcidid>0000-0002-3570-9904 ; 0000-0003-1026-9401 ; 0000-0002-0113-6810 ; 0000-0001-6777-3225 ; 0000-0001-9746-1708 ; 0000-0002-6049-0588 ; 0000-0003-0163-0146 ; 0000-0003-1718-7070 ; 0000-0002-4550-5729</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355272/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355272/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Leite, Karla Lorene de França</creatorcontrib><creatorcontrib>Martins, Mariana Leonel</creatorcontrib><creatorcontrib>Dias, Millene de Oliveira</creatorcontrib><creatorcontrib>Tavares, Fernanda Oliveira Miranda</creatorcontrib><creatorcontrib>Justino, Isabella Barbosa dos Santos</creatorcontrib><creatorcontrib>Cabral, Lúcio Mendes</creatorcontrib><creatorcontrib>Neves, Aline de Almeida</creatorcontrib><creatorcontrib>Cavalcanti, Yuri Wanderley</creatorcontrib><creatorcontrib>Maia, Lucianne Cople</creatorcontrib><title>In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution</title><title>Brazilian dental journal</title><description>To assess the in vitro and in situ effect of experimental combined fluoride and calcium nanocomposite solutions on dental caries prevention. Nanocompound mesoporous silica (MS) with calcium (Ca) and sodium fluoride (NaF) - (MSCaNaF); MS with NaF (MSNaF), NaF solution (positive control), and deionized water (negative control - CG) were studied. The specimens (n=130) were submitted in vitro to a multispecies biofilm in the presence of 2% sucrose. After 24 h and 48 h, the culture medium pH, the percent of surface mineral loss (%SML), and lesion depth (ΔZ) were analyzed. In the in situ study, 10 volunteers participated in four phases of 7-days each. The products were applied on the specimens (n=240) before 20% sucrose solution drips. The polysaccharides (SEPS and IEPS), %SML and roughness (Sa) were evaluated. There was an in vitro decrease in pH values in 24h and 48h, compared to baseline. The MSCaNaF and MSNaF groups obtained lower values of %SML and ΔZ (p &lt; 0.05) than CG and NaF after 24h and were similar to NaF after 48h (p&lt;0.05). In situ results showed similar SEPS and IEPS among all groups after 48h. An after 7-days, the nanocomposites had similar values (p&gt;0.05), while NaF was similar to CG (p&gt;0.05). After 48h, the MSCaNaF and MSNaF reduced the %SML (p&lt;0.05). After 7-days, both experimental nanocomposites were similar to NaF (p&gt;0.05). Regarding Sa, MSCaNaF was better than NaF for both periods (p&lt;0.05). The nanocomposites controlled the in vitro and in situ enamel demineralization, mainly in the initial periods.</description><issn>0103-6440</issn><issn>1806-4760</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVkc1OwzAQhC0EoqXwApz8AgHb6zjJCaGKn0qVuMA5cp01GKV25PxQ3h5DUaWe9jAzn0Y7hFxzdsPzit0yziBTUjLBBLBcKnZC5rxkKpOFYqdkfjDMyEXff7JklFCdkxkUUqmcV3OyW3k6uSEGqn1Dnae9G0ZqdHTYZ13ECf3gJqRoLZqBBks19fhFTdhunMeG2nYM0TX4lze6NW7cUtx1GN02ZXVLvfYh2buQ0Ej70I6DC_6SnFnd9nj1fxfk7fHhdfmcrV-eVsv7dWaAlSxToBCVyaEoy4pZw7lQEkAZ2WCpWFJLUYDdlA0AF2CxqCwYlUtRKq0twILc7bnduNliY1KnqNu6S_V0_K6DdvWx4t1H_R6mOv0uz0UhEkHsCSaGvo9oD2HO6t8h6t8_10dDwA_iI3v7</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Leite, Karla Lorene de França</creator><creator>Martins, Mariana Leonel</creator><creator>Dias, Millene de Oliveira</creator><creator>Tavares, Fernanda Oliveira Miranda</creator><creator>Justino, Isabella Barbosa dos Santos</creator><creator>Cabral, Lúcio Mendes</creator><creator>Neves, Aline de Almeida</creator><creator>Cavalcanti, Yuri Wanderley</creator><creator>Maia, Lucianne Cople</creator><general>Fundação Odontológica de Ribeirão Preto</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3570-9904</orcidid><orcidid>https://orcid.org/0000-0003-1026-9401</orcidid><orcidid>https://orcid.org/0000-0002-0113-6810</orcidid><orcidid>https://orcid.org/0000-0001-6777-3225</orcidid><orcidid>https://orcid.org/0000-0001-9746-1708</orcidid><orcidid>https://orcid.org/0000-0002-6049-0588</orcidid><orcidid>https://orcid.org/0000-0003-0163-0146</orcidid><orcidid>https://orcid.org/0000-0003-1718-7070</orcidid><orcidid>https://orcid.org/0000-0002-4550-5729</orcidid></search><sort><creationdate>20230601</creationdate><title>In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution</title><author>Leite, Karla Lorene de França ; Martins, Mariana Leonel ; Dias, Millene de Oliveira ; Tavares, Fernanda Oliveira Miranda ; Justino, Isabella Barbosa dos Santos ; Cabral, Lúcio Mendes ; Neves, Aline de Almeida ; Cavalcanti, Yuri Wanderley ; Maia, Lucianne Cople</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3080-636ee6c5378890fc11264336c4de86036e8273fb8d33123fe79f3c654286aaf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leite, Karla Lorene de França</creatorcontrib><creatorcontrib>Martins, Mariana Leonel</creatorcontrib><creatorcontrib>Dias, Millene de Oliveira</creatorcontrib><creatorcontrib>Tavares, Fernanda Oliveira Miranda</creatorcontrib><creatorcontrib>Justino, Isabella Barbosa dos Santos</creatorcontrib><creatorcontrib>Cabral, Lúcio Mendes</creatorcontrib><creatorcontrib>Neves, Aline de Almeida</creatorcontrib><creatorcontrib>Cavalcanti, Yuri Wanderley</creatorcontrib><creatorcontrib>Maia, Lucianne Cople</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brazilian dental journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leite, Karla Lorene de França</au><au>Martins, Mariana Leonel</au><au>Dias, Millene de Oliveira</au><au>Tavares, Fernanda Oliveira Miranda</au><au>Justino, Isabella Barbosa dos Santos</au><au>Cabral, Lúcio Mendes</au><au>Neves, Aline de Almeida</au><au>Cavalcanti, Yuri Wanderley</au><au>Maia, Lucianne Cople</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution</atitle><jtitle>Brazilian dental journal</jtitle><date>2023-06-01</date><risdate>2023</risdate><volume>34</volume><issue>3</issue><spage>119</spage><epage>128</epage><pages>119-128</pages><issn>0103-6440</issn><eissn>1806-4760</eissn><abstract>To assess the in vitro and in situ effect of experimental combined fluoride and calcium nanocomposite solutions on dental caries prevention. Nanocompound mesoporous silica (MS) with calcium (Ca) and sodium fluoride (NaF) - (MSCaNaF); MS with NaF (MSNaF), NaF solution (positive control), and deionized water (negative control - CG) were studied. The specimens (n=130) were submitted in vitro to a multispecies biofilm in the presence of 2% sucrose. After 24 h and 48 h, the culture medium pH, the percent of surface mineral loss (%SML), and lesion depth (ΔZ) were analyzed. In the in situ study, 10 volunteers participated in four phases of 7-days each. The products were applied on the specimens (n=240) before 20% sucrose solution drips. The polysaccharides (SEPS and IEPS), %SML and roughness (Sa) were evaluated. There was an in vitro decrease in pH values in 24h and 48h, compared to baseline. The MSCaNaF and MSNaF groups obtained lower values of %SML and ΔZ (p &lt; 0.05) than CG and NaF after 24h and were similar to NaF after 48h (p&lt;0.05). In situ results showed similar SEPS and IEPS among all groups after 48h. An after 7-days, the nanocomposites had similar values (p&gt;0.05), while NaF was similar to CG (p&gt;0.05). After 48h, the MSCaNaF and MSNaF reduced the %SML (p&lt;0.05). After 7-days, both experimental nanocomposites were similar to NaF (p&gt;0.05). Regarding Sa, MSCaNaF was better than NaF for both periods (p&lt;0.05). The nanocomposites controlled the in vitro and in situ enamel demineralization, mainly in the initial periods.</abstract><pub>Fundação Odontológica de Ribeirão Preto</pub><pmid>37466519</pmid><doi>10.1590/0103-6440202305460</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3570-9904</orcidid><orcidid>https://orcid.org/0000-0003-1026-9401</orcidid><orcidid>https://orcid.org/0000-0002-0113-6810</orcidid><orcidid>https://orcid.org/0000-0001-6777-3225</orcidid><orcidid>https://orcid.org/0000-0001-9746-1708</orcidid><orcidid>https://orcid.org/0000-0002-6049-0588</orcidid><orcidid>https://orcid.org/0000-0003-0163-0146</orcidid><orcidid>https://orcid.org/0000-0003-1718-7070</orcidid><orcidid>https://orcid.org/0000-0002-4550-5729</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0103-6440
ispartof Brazilian dental journal, 2023-06, Vol.34 (3), p.119-128
issn 0103-6440
1806-4760
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10355272
source SciELO Brazil; PubMed Central
title In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T05%3A08%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vitro%20and%20in%20situ%20caries-preventive%20effect%20of%20a%20new%20combined%20fluoride%20and%20calcium%20experimental%20nanocomposite%20solution&rft.jtitle=Brazilian%20dental%20journal&rft.au=Leite,%20Karla%20Lorene%20de%20Fran%C3%A7a&rft.date=2023-06-01&rft.volume=34&rft.issue=3&rft.spage=119&rft.epage=128&rft.pages=119-128&rft.issn=0103-6440&rft.eissn=1806-4760&rft_id=info:doi/10.1590/0103-6440202305460&rft_dat=%3Cpubmedcentral_cross%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_10355272%3C/pubmedcentral_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3080-636ee6c5378890fc11264336c4de86036e8273fb8d33123fe79f3c654286aaf33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/37466519&rfr_iscdi=true