Prospective Cohort Study of Ginseng Consumption in Association with Cancer Risk: Shanghai Women’s Health Study

Ginseng has been commonly used in Asian countries to promote longevity and health for >2000 years. Recent in vitro and in vivo studies, coupled with limited epidemiologic studies, have suggested that regular ginseng consumption may be related to lower cancer risk. We evaluated the association of...

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Bibliographic Details
Published in:The Journal of nutrition 2023-04, Vol.153 (4), p.1170-1177
Main Authors: Pradhan, Pranoti, Wen, Wanqing, Cai, Hui, Gao, Yu-Tang, Shu, Xiao-ou, Zheng, Wei
Format: Article
Language:English
Subjects:
Asian
Cancer
China
China - epidemiology
Cohort analysis
Cohort Studies
complementary medicine
Consumption
Diet
Epidemiology
Female
females
Flowers & plants
Ginseng
Health
Health risks
Herbal medicine
Humans
In vivo methods and tests
incidence
Liver cancer
Liver Neoplasms
longevity
Lymphoma
Malignancy
Middle Aged
Non-Hodgkin's lymphoma
Nutrition
Nutritional Epidemiology
Panax
Prospective Studies
Risk
Risk Factors
Risk reduction
Statistical models
Thyroid
Thyroid cancer
thyroid neoplasms
Women's Health
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Summary:Ginseng has been commonly used in Asian countries to promote longevity and health for >2000 years. Recent in vitro and in vivo studies, coupled with limited epidemiologic studies, have suggested that regular ginseng consumption may be related to lower cancer risk. We evaluated the association of ginseng consumption with risk of total and 15 site-specific cancers in a large cohort study conducted among Chinese women. Given the previous literature on ginseng consumption and cancer risk, we hypothesized that ginseng consumption might be associated with varying risks of cancer. This study included 65,732 female participants (mean age: 52.2 years) of the Shanghai Women’s Health Study, an ongoing prospective cohort study. Baseline enrollment occurred between 1997 and 2000, and follow-up concluded on 31 December 2016. Ginseng use and covariates were assessed via an in-person interview conducted at the baseline recruitment. The cohort was followed for cancer incidence. Cox proportional hazard models were used to estimate HRs and 95% CIs for ginseng-cancer associations after adjusting for confounders. During a mean 14.7 years of follow-up, 5067 incident cancer cases were identified. Overall, regular ginseng use was mostly not associated with risk of any site-specific cancer, or all cancers combined. Short-term (
ISSN:0022-3166
1541-6100
DOI:10.1016/j.tjnut.2023.02.032