A rare presentation of a spinal diffuse midline glioma in a child: a case report

Our patient had an extremely rare type of pediatric Diffuse Midline Glioma (DMG) with modified H3 K27 that occurred in the cervical spinal cord. Due to its location in the spinal cord, slow clinical presentation with torticollis for 7 months, and the non-specific radiological appearance of this tumo...

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Bibliographic Details
Published in:The Pan African medical journal 2023, Vol.44, p.183
Main Authors: Isfaoun, Zineb, Laasri, Khadija, Jidal, Manal, Cherradi, Nadia, Melhaoui, Adil, Chat, Latifa, Haddad, Siham El, Kababri, Maria El, Khorassani, Mohamed El, Kili, Amina, Ansari, Naoual El, Hessissen, Laila
Format: Article
Language:English
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Case Report
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Summary:Our patient had an extremely rare type of pediatric Diffuse Midline Glioma (DMG) with modified H3 K27 that occurred in the cervical spinal cord. Due to its location in the spinal cord, slow clinical presentation with torticollis for 7 months, and the non-specific radiological appearance of this tumour, it was initially considered to be a low-grade glioma. Based on imaging findings, the neurosurgery team performed a complete surgical resection, but the pathological features were consistent with a high-grade, diffuse midline glioma. Therefore, we are reporting a case of an altered high-grade DMG H3K27 glioma, which is difficult to diagnose due to its slow clinical symptoms which caused a delay in diagnosis, non-specific imaging, and with difficulty in accessing histopathological markers in low and middle income countries (LMIC).
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2023.44.183.39885