The heterocellular heart: identities, interactions, and implications for cardiology

The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial cells, fibroblasts, or immune cells are coming more into focus. The rise of single-cell sequencin...

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Bibliographic Details
Published in:Basic research in cardiology 2023-07, Vol.118 (1), p.30, Article 30
Main Authors: Lother, Achim, Kohl, Peter
Format: Article
Language:English
Subjects:
Cardiology
Cardiomyocytes
Cells
Endothelial Cells
Fibroblasts
Fibroblasts - metabolism
Gap Junctions
Gene expression
Growth factors
Heart
Homeostasis
Immune system
Invited Review
Medicine
Medicine & Public Health
Myocytes
Myocytes, Cardiac - metabolism
Smooth muscle
Therapeutic applications
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Summary:The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes such as endothelial cells, fibroblasts, or immune cells are coming more into focus. The rise of single-cell sequencing technologies enables  identification of ever more subtle differences and has reignited the question of what defines a cell’s identity. Here we provide an overview of the major cardiac cell types, describe their roles in homeostasis, and outline recent findings on non-canonical functions that may be of relevance for cardiology. We highlight modes of biochemical and biophysical interactions between different cardiac cell types and discuss the potential implications of the heterocellular nature of the heart for basic research and therapeutic interventions.
ISSN:1435-1803
0300-8428
1435-1803
DOI:10.1007/s00395-023-01000-6