Prognostic factors after resection of locally advanced non-functional pancreatic neuroendocrine neoplasm: an analysis from the German Cancer Registry Group of the Society of German Tumor Centers

Objective The available literature regarding outcome after pancreatic resection in locally advanced non-functional pNEN (LA-pNEN) is sparse. Therefore, this study evaluates the current survival outcomes and prognostic factors in after resection of LA-pNEN. Materials and methods This population-based...

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Published in:Journal of cancer research and clinical oncology 2023-09, Vol.149 (11), p.8535-8543
Main Authors: Abdalla, Thaer S. A., Klinkhammer-Schalke, Monika, Zeissig, Sylke Ruth, Tol, Kees Kleihues-van, Honselmann, Kim C., Braun, Rüdiger, Bolm, Louisa, Lapshyn, Hryhoriy, Litkevych, Stanislav, Zemskov, Sergii, Begum, Nehara, Kulemann, Birte, Hummel, Richard, Wellner, Ulrich Friedrich, Keck, Tobias, Deichmann, Steffen
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cancer Research
Female
Hematology
Humans
Internal Medicine
Lymph nodes
Lymphatic Metastasis
Lymphatic system
Male
Margins of Excision
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Middle Aged
Neoplasm Staging
Neuroendocrine tumors
Neuroendocrine Tumors - pathology
Oncology
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - pathology
Prognosis
Registries
Retrospective Studies
Risk groups
Survival
Tumors
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Summary:Objective The available literature regarding outcome after pancreatic resection in locally advanced non-functional pNEN (LA-pNEN) is sparse. Therefore, this study evaluates the current survival outcomes and prognostic factors in after resection of LA-pNEN. Materials and methods This population-based analysis was derived from 17 German cancer registries from 2000 to 2019. Patients with upfront resected non-functional non-metastatic LA-pNEN were included. Results Out of 2776 patients with pNEN, 277 met the inclusion criteria. 137 (45%) of the patients were female. The median age was 63 ± 18 years. Lymph node metastasis was present in 45%. G1, G2 and G3 pNEN were found in 39%, 47% and 14% of the patients, respectively. Resection of LA-pNEN resulted in favorable 3-, 5- and 10-year overall survival of 79%, 74%, and 47%. Positive resection margin was the only potentially modifiable independent prognostic factor for overall survival (HR 1.93, 95% CI 1.71–3.69, p value = 0.046), whereas tumor grade G3 (HR 5.26, 95% CI 2.09–13.25, p value 
ISSN:0171-5216
1432-1335
1432-1335
DOI:10.1007/s00432-023-04785-0