Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone

Abstract The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We di...

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Bibliographic Details
Published in:Open forum infectious diseases 2023-07, Vol.10 (7), p.ofad379-ofad379
Main Authors: Stek, Cari, Shey, Muki, Mnika, Khuthala, Schutz, Charlotte, Thienemann, Friedrich, Wilkinson, Robert J, Lynen, Lutgarde, Meintjes, Graeme
Format: Article
Language:English
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Brief Report
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Summary:Abstract The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad379