The Absolute Monocyte Count at Diagnosis Affects Prognosis in Myelodysplastic Syndromes Independently of the IPSS-R Risk Score

The absolute monocyte count (AMC) is associated with mortality in a variety of medical conditions. Its prognostic impact in myelodysplastic syndromes (MDSs) is less well studied. Therefore, we investigated its potential prognostic value in a cohort from the Düsseldorf MDS registry in relationship to...

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Bibliographic Details
Published in:Cancers 2023-07, Vol.15 (14), p.3572
Main Authors: Silzle, Tobias, Blum, Sabine, Kasprzak, Annika, Nachtkamp, Kathrin, Rudelius, Martina, Hildebrandt, Barbara, Götze, Katharina S, Gattermann, Norbert, Lauseker, Michael, Germing, Ulrich
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Allografts
Blood
Bone marrow
Chemotherapy
Cytogenetics
Diagnosis
Germany
Health aspects
Hemoglobin
Leukemia
Leukocytes (neutrophilic)
Medical prognosis
Metaphase
Monocytes
Monocytosis
Mortality
Mutation
Myelodysplastic syndrome
Myelodysplastic syndromes
Neutrophils
Older people
Patients
Prognosis
Risk factors
Stem cell transplantation
Transplantation
Tumors
Variables
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Summary:The absolute monocyte count (AMC) is associated with mortality in a variety of medical conditions. Its prognostic impact in myelodysplastic syndromes (MDSs) is less well studied. Therefore, we investigated its potential prognostic value in a cohort from the Düsseldorf MDS registry in relationship to the revised international prognostic scoring system (IPSS-R). An AMC below the population's median (
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15143572