Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis

complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-07, Vol.24 (14), p.11385
Main Authors: Cavalcante-Silva, Luiz Henrique Agra, Almeida, Fernanda Silva, Andrade, Arthur Gomes de, Comberlang, Fernando Cézar, Cardoso, Leonardo Lima, Vanderley, Shayenne Eduarda Ramos, Keesen, Tatjana S L
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antimicrobial Peptides
Asymptomatic
Bone marrow
Chemokines
Cytokines
Dendritic cells
Drug resistance
Extracellular Traps
Granulomas
Humans
Immune system
Immunology
Infections
Infectious diseases
Inflammation
Lungs
Lymphatic system
Lymphocytes
Mycobacterium tuberculosis
Neutrophils
Pathogenesis
Reactive oxygen species
Review
Tuberculosis
Vaccines
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Summary:complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241411385