Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study

Liver disease is often associated with dysfunctional potassium homeostasis but is not a well-established risk factor for hyperkalemia. This retrospective cohort study examined the potential relationship between liver disease and recurrent hyperkalemia. Patients with ≥1 serum potassium measurement be...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2023-07, Vol.12 (14), p.4562
Main Authors: Ahdoot, Rebecca S, Hsiung, Jui-Ting, Agiro, Abiy, Brahmbhatt, Yasmin G, Cooper, Kerry, Fawaz, Souhiela, Westfall, Laura, Kalantar-Zadeh, Kamyar, Streja, Elani
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Cancer
Chronic obstructive pulmonary disease
Clinical medicine
Cohort analysis
Comorbidity
Complications and side effects
Diabetes
Diseases
Diuretics
Ethnicity
Heart attacks
Heart failure
Hispanic Americans
HIV
Human immunodeficiency virus
Hyperkalemia
Immune system
Liver cirrhosis
Liver diseases
Mortality
Paralysis
Patients
Prognosis
Regression analysis
Relapse
Risk factors
Ulcers
Veterans
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Liver disease is often associated with dysfunctional potassium homeostasis but is not a well-established risk factor for hyperkalemia. This retrospective cohort study examined the potential relationship between liver disease and recurrent hyperkalemia. Patients with ≥1 serum potassium measurement between January 2004 and December 2018 who experienced hyperkalemia (serum potassium >5.0 mmol/L) were identified from the United States Veterans Affairs database. A competing risk regression model was used to analyze the relationship between patient characteristics and recurrent hyperkalemia. Of 1,493,539 patients with incident hyperkalemia, 71,790 (4.8%) had liver disease (one inpatient or two outpatient records) within 1 year before the index hyperkalemia event. Recurrent hyperkalemia within 1 year after the index event occurred in 234,807 patients (15.7%) overall, 19,518 (27.2%) with liver disease, and 215,289 (15.1%) without liver disease. The risk of recurrent hyperkalemia was significantly increased in patients with liver disease versus those without (subhazard ratio, 1.34; 95% confidence interval, 1.32-1.37; < 0.0001). Aside from vasodilator therapy, the risk of recurrent hyperkalemia was not increased with concomitant medication. In this cohort study, liver disease was an independent risk factor strongly associated with recurrent hyperkalemia within 1 year, independent of concomitant renin-angiotensin-aldosterone system inhibitor or potassium-sparing diuretic use.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12144562