Semen Cryopreservation for Men Banking for Oligozoospermia, Cancers, and Other Conditions: 24 Years' Experience of an Italian Bank

Sperm cryopreservation is recommended to preserve male fertility for cancer patients or other medical conditions at risk of sperm decline. Whether motility and viability recovery rates vary depending on the medical conditions requiring cryopreservation is poorly known. We report here on the 24-year...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-07, Vol.12 (14), p.4657
Main Authors: Marchiani, Sara, Degl'Innocenti, Selene, Dabizzi, Sara, Tamburrino, Lara, Fino, Maria Grazia, Traini, Giulia, Calamai, Costanza, Maggi, Mario, Vignozzi, Linda, Baldi, Elisabetta, Lotti, Francesco
Format: Article
Language:English
Subjects:
Cancer
Clinical medicine
Cryopreservation
Cryopreservation of organs, tissues, etc
Fertility
Methods
Morphology
Motility
Nitrogen
Patients
Quality management
Services
Sperm
Sperm banks
Spermatozoa
Spinal cord injuries
Statistical analysis
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Summary:Sperm cryopreservation is recommended to preserve male fertility for cancer patients or other medical conditions at risk of sperm decline. Whether motility and viability recovery rates vary depending on the medical conditions requiring cryopreservation is poorly known. We report here on the 24-year experience of our semen bank. Motility and viability recovery rates were evaluated in 1973 collections from patients with various medical conditions and 67 collections from donors, and the results were related to basal semen quality. Motility and viability recovery were highly related to basal semen quality and varied between cancer and non-cancer conditions, independently of the duration of cryopreservation and patient age. In samples with a sperm number below 2 × 10 /mL, recovery rates approximated to zero. The highest recovery rates were found in donor collections. Cut-off values for the recovery of at least 1% motile spermatozoa were established based on initial semen quality. Our results indicate that the occurrence of any pathological or medical condition resulted in lower recovery rates with respect to donors, indicating that intrinsic sperm characteristics drive susceptibility to cryodamage. Established cut-off values for motility recovery can be useful for patient counseling as well as for ART laboratories to decide the type of procedure.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12144657