Apelin-13 as a Potential Biomarker in Critical Illness

The adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and...

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Published in:Journal of clinical medicine 2023-07, Vol.12 (14), p.4801
Main Authors: Gergics, Marin, Pham-Dobor, Gréta, Kurdi, Csilla, Montskó, Gergely, Mihályi, Krisztina, Bánfai, Gábor, Kanizsai, Péter, Kőszegi, Tamás, Mezősi, Emese, Bajnok, László
Format: Article
Language:English
Subjects:
Automation
Biological markers
Biomarkers
Clinical medicine
Critical care
Critically ill
Health aspects
Homeostasis
Hormones
Hypotension
Hypothalamus
Intensive care
Kidneys
Laboratories
Measurement
Medical research
Medicine, Experimental
Metabolism
Mortality
Normal distribution
Peptide hormones
Potassium
Prognosis
Regression analysis
Sepsis
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Summary:The adrenocortical system and copeptin as prognostic markers were intensively investigated in critical illness. The potential predictive power of apelin-13 as a biomarker is largely unknown. We aimed to investigate the prognostic role of apelin-13 in relation to free cortisol, aldosterone, CRH, and copeptin in critically ill patients. In this prospective observational study, 124 critically ill patients (64 men, 60 women, median age: 70 (59-78) years) were consecutively enrolled at the time of admission. All routinely available clinical and laboratory parameters were evaluated and correlated to hormonal changes. Serum apelin-13 was 1161 (617-2967) pg/mL in non-survivors vs. 2477 (800-3531) pg/mL in survivors ( = 0.054). The concentrations of apelin-13 and CRH had strong positive correlations (r = 0.685, < 0.001) and were significantly higher in surviving non-septic patients (Apelin-13 (pg/mL): 2286 (790-3330) vs. 818 (574-2732) < 0.05; CRH (pg/mL) 201 (84-317) vs. 89 (74-233) < 0.05). Apelin-13 and free cortisol were independent determinants of survival in the multivariate Cox regression analysis, while copeptin, CRH, or aldosterone were not. Beyond free cortisol, serum apelin-13 may also help refine prognostic predictions in the early phase of critical illness, especially in non-septic patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12144801