MicroRNAs Associated with the Pathophysiological Mechanisms of Gestational Diabetes Mellitus: A Systematic Review for Building a Panel of miRNAs

miRNAs, a class of small non-coding RNAs, play a role in post-transcriptional gene expression. Therefore, this study aimed to conduct a systematic review of miRNAs associated with GDM to build a panel of miRNAs. A bibliographic search was carried out in the PubMed/Medline, Virtual Health Library (VH...

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Bibliographic Details
Published in:Journal of personalized medicine 2023-07, Vol.13 (7), p.1126
Main Authors: da Silva, Pedro Henrique Costa Matos, Santos, Kamilla de Faria, da Silva, Laura, da Costa, Caroline Christine Pincela, Santos, Rodrigo da Silva, Reis, Angela Adamski da Silva
Format: Article
Language:English
Subjects:
Adaptation
Beta cells
Bias
Biomarkers
Cell cycle
Cell proliferation
Cohort analysis
Confounding (Statistics)
Cross-sectional studies
Diabetes in pregnancy
Diabetes mellitus
Fetuses
Gene expression
Genetic aspects
Genetic transcription
Gestational diabetes
Glucose
Glucose metabolism
Homeostasis
Insulin secretion
Metabolism
MicroRNA
MicroRNAs
miRNA
Physiological aspects
Placenta
Post-transcription
Precision medicine
Pregnancy
Reviews
Systematic Review
Type 2 diabetes
Womens health
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Summary:miRNAs, a class of small non-coding RNAs, play a role in post-transcriptional gene expression. Therefore, this study aimed to conduct a systematic review of miRNAs associated with GDM to build a panel of miRNAs. A bibliographic search was carried out in the PubMed/Medline, Virtual Health Library (VHL), Web of Science, and EMBASE databases, selecting observational studies in English without time restriction. The protocol was registered on the PROSPERO platform (number CRD42021291791). Fifty-five studies were included in this systematic review, and 82 altered miRNAs in GDM were identified. In addition, four miRNAs were most frequently dysregulated in GDM (mir-16-5p, mir-20a-5p, mir-222-3p, and mir-330-3p). The dysregulation of these miRNAs is associated with the mechanisms of cell cycle homeostasis, growth, and proliferation of pancreatic β cells, glucose uptake and metabolism, insulin secretion, and resistance. On the other hand, identifying miRNAs associated with GDM and elucidating its main mechanisms can assist in the characterization and definition of potential biomarkers for the diagnosis and treatment of GDM.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm13071126