Pediatric sepsis diagnostic and prognostic biomarkers: pancreatic stone protein, copeptin, and apolipoprotein A-V

Background We assessed serum concentrations of pancreatic stone protein (PSP), copeptin, and apolipoprotein A-V (APOA5) biomarkers for the diagnosis and prognosis of pediatric sepsis, a condition associated with high mortality. Methods This prospective study included 180 children admitted to the Ped...

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Bibliographic Details
Published in:Pediatric research 2023-08, Vol.94 (2), p.668-675
Main Authors: Saleh, Nagwan Y., Aboelghar, Hesham M., Garib, Mohamed I., Rizk, Mohammed S., Mahmoud, Asmaa A.
Format: Article
Language:English
Subjects:
Apolipoprotein A-V
Apolipoproteins
Biomarkers
Child
Clinical
Clinical Research Article
Humans
Lithostathine
Medicine
Medicine & Public Health
Mortality
Pediatric Surgery
Pediatrics
Prognosis
Prospective Studies
Proteins
ROC Curve
Sepsis
Sepsis - diagnosis
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Summary:Background We assessed serum concentrations of pancreatic stone protein (PSP), copeptin, and apolipoprotein A-V (APOA5) biomarkers for the diagnosis and prognosis of pediatric sepsis, a condition associated with high mortality. Methods This prospective study included 180 children admitted to the Pediatric Intensive Care Unit and 100 healthy controls at Menoufia University Hospital. Pediatric Risk of Mortality (PRISM), Pediatric Index of Mortality-2 (PIM2), and Pediatric Sequential Organ Failure Assessment (pSOFA) scores were calculated. Serum PSP, copeptin and APOA5 were measured once within 24 h of admission. Results PSP, copeptin, and APOA5 were significantly higher in the patients than in the controls ( p  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-023-02499-0