An Uncommon Case of Recurrent Hypoglycemic Episodes in a Healthy Non-diabetic Male: Insulin Autoimmune Syndrome

Insulin autoimmune syndrome is a rare cause of recurrent hypoglycemic episodes that can mimic various other pathological problems leading to unnecessary diagnostic assessments and interventions. Here, we report a case of a healthy non-diabetic male in his 50s presenting with recurrent episodes of hy...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-06, Vol.15 (6), p.e41183
Main Authors: Dhaliwal, Kanwarpal K, Bector, Gaurav, Arora, Saurabh, Singh, Amanpreet, Kalra, Sanjay
Format: Article
Language:English
Subjects:
Abdomen
Allergy/Immunology
Anemia
Antibodies
Asymptomatic
Autoimmune diseases
Blood diseases
Case reports
Diabetes
Drug dosages
Endocrinology/Diabetes/Metabolism
Ethnicity
Family medical history
Glucose
Hemoglobin
Hormones
Hyperglycemia
Hypoglycemia
Insulin
Internal Medicine
Pathophysiology
Patients
Peptides
Steroids
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Summary:Insulin autoimmune syndrome is a rare cause of recurrent hypoglycemic episodes that can mimic various other pathological problems leading to unnecessary diagnostic assessments and interventions. Here, we report a case of a healthy non-diabetic male in his 50s presenting with recurrent episodes of hypoglycemia with no prior exposure to exogenous insulin. During a 72-hour fasting test, his glucose levels reached 22 mg/dl within less than three hours. The lab tests showed insulin of 1000 μIU/mL and C-peptide of 4.99 ng/ml. On further evaluation, high titers of insulin autoantibodies (IAA) >100 U/ml (normal =
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.41183