Design and in vitro, in vivo evaluation of antioxidant bioadhesive gels for burn treatment

Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine...

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Bibliographic Details
Published in:Turkish journal of biology 2022, Vol.46 (3), p.251-262
Main Authors: Gökçe, Göksel, Karavana, Sinem Yaprak, Bağriyanik, Alper, Pekçetin, Çetin, Algin Yapar, Evren, Aybar Tural, Gülşen, Gökçe, Evren Homan
Format: Article
Language:English
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Summary:Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by balancing oxidative stress.
ISSN:1300-0152
1303-6092
DOI:10.55730/1300-0152.2613