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Patterns in the Development of Pediatric Allergy
Describe clinical and epidemiologic patterns of pediatric allergy using longitudinal electronic health records (EHRs) from a multistate consortium of US practices. Using the multistate Comparative Effectiveness Research through Collaborative Electronic Reporting EHR database, we defined a cohort of...
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Published in: | Pediatrics (Evanston) 2023-08, Vol.152 (2), p.1 |
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creator | Gabryszewski, Stanislaw J Dudley, Jesse Shu, Di Faerber, Jennifer A Grundmeier, Robert W Fiks, Alexander G Hill, David A |
description | Describe clinical and epidemiologic patterns of pediatric allergy using longitudinal electronic health records (EHRs) from a multistate consortium of US practices.
Using the multistate Comparative Effectiveness Research through Collaborative Electronic Reporting EHR database, we defined a cohort of 218 485 children (0-18 years) who were observed for ≥5 years between 1999 and 2020. Children with atopic dermatitis (AD), immunoglobulin E-mediated food allergy (IgE-FA), asthma, allergic rhinitis (AR), and eosinophilic esophagitis (EoE) were identified using a combination of diagnosis codes and medication prescriptions. We determined age at diagnosis, cumulative incidence, and allergic comorbidity.
Allergic disease cumulative (and peak age of) incidence was 10.3% (4 months) for AD, 4.0% (13 months) for IgE-FA, 20.1% (13 months) for asthma, 19.7% (26 months) for AR, and 0.11% (35 months) for EoE. The most diagnosed IgE-FAs were peanut (1.9%), egg (0.8%), and shellfish (0.6%). A total of 13.4% of children had ≥2 allergic conditions, and respiratory allergies (ie, asthma, AR) were commonly comorbid with each other, and with other allergic conditions.
We detail pediatric allergy patterns using longitudinal, health care provider-based data from EHR systems across multiple US states and varied pediatric practice types. Our results support the population-level allergic march progression and indicate high rates of comorbidity among children with food and respiratory allergies. |
doi_str_mv | 10.1542/peds.2022-060531 |
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Using the multistate Comparative Effectiveness Research through Collaborative Electronic Reporting EHR database, we defined a cohort of 218 485 children (0-18 years) who were observed for ≥5 years between 1999 and 2020. Children with atopic dermatitis (AD), immunoglobulin E-mediated food allergy (IgE-FA), asthma, allergic rhinitis (AR), and eosinophilic esophagitis (EoE) were identified using a combination of diagnosis codes and medication prescriptions. We determined age at diagnosis, cumulative incidence, and allergic comorbidity.
Allergic disease cumulative (and peak age of) incidence was 10.3% (4 months) for AD, 4.0% (13 months) for IgE-FA, 20.1% (13 months) for asthma, 19.7% (26 months) for AR, and 0.11% (35 months) for EoE. The most diagnosed IgE-FAs were peanut (1.9%), egg (0.8%), and shellfish (0.6%). A total of 13.4% of children had ≥2 allergic conditions, and respiratory allergies (ie, asthma, AR) were commonly comorbid with each other, and with other allergic conditions.
We detail pediatric allergy patterns using longitudinal, health care provider-based data from EHR systems across multiple US states and varied pediatric practice types. Our results support the population-level allergic march progression and indicate high rates of comorbidity among children with food and respiratory allergies.</description><identifier>ISSN: 0031-4005</identifier><identifier>ISSN: 1098-4275</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2022-060531</identifier><identifier>PMID: 37489286</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Allergic rhinitis ; Asthma ; Asthma - diagnosis ; Asthma - drug therapy ; Asthma - epidemiology ; Atopic dermatitis ; Child ; Children ; Comorbidity ; Dermatitis, Atopic - diagnosis ; Dermatitis, Atopic - epidemiology ; Diagnosis ; Electronic health records ; Electronic medical records ; Eosinophilic Esophagitis - diagnosis ; Eosinophilic Esophagitis - epidemiology ; Epidemiology ; Esophagitis ; Food allergies ; Food Hypersensitivity - diagnosis ; Humans ; Immunoglobulin E ; Infant ; Leukocytes (eosinophilic) ; Pediatrics ; Rhinitis, Allergic - epidemiology</subject><ispartof>Pediatrics (Evanston), 2023-08, Vol.152 (2), p.1</ispartof><rights>Copyright © 2023 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Aug 2023</rights><rights>Copyright © 2023 by the American Academy of Pediatrics 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-bd386a818cf9510e981cc9ae0d2efdfc1811d5f79c33aad80db7e67b94c327d03</citedby><cites>FETCH-LOGICAL-c491t-bd386a818cf9510e981cc9ae0d2efdfc1811d5f79c33aad80db7e67b94c327d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37489286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabryszewski, Stanislaw J</creatorcontrib><creatorcontrib>Dudley, Jesse</creatorcontrib><creatorcontrib>Shu, Di</creatorcontrib><creatorcontrib>Faerber, Jennifer A</creatorcontrib><creatorcontrib>Grundmeier, Robert W</creatorcontrib><creatorcontrib>Fiks, Alexander G</creatorcontrib><creatorcontrib>Hill, David A</creatorcontrib><title>Patterns in the Development of Pediatric Allergy</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Describe clinical and epidemiologic patterns of pediatric allergy using longitudinal electronic health records (EHRs) from a multistate consortium of US practices.
Using the multistate Comparative Effectiveness Research through Collaborative Electronic Reporting EHR database, we defined a cohort of 218 485 children (0-18 years) who were observed for ≥5 years between 1999 and 2020. Children with atopic dermatitis (AD), immunoglobulin E-mediated food allergy (IgE-FA), asthma, allergic rhinitis (AR), and eosinophilic esophagitis (EoE) were identified using a combination of diagnosis codes and medication prescriptions. We determined age at diagnosis, cumulative incidence, and allergic comorbidity.
Allergic disease cumulative (and peak age of) incidence was 10.3% (4 months) for AD, 4.0% (13 months) for IgE-FA, 20.1% (13 months) for asthma, 19.7% (26 months) for AR, and 0.11% (35 months) for EoE. The most diagnosed IgE-FAs were peanut (1.9%), egg (0.8%), and shellfish (0.6%). A total of 13.4% of children had ≥2 allergic conditions, and respiratory allergies (ie, asthma, AR) were commonly comorbid with each other, and with other allergic conditions.
We detail pediatric allergy patterns using longitudinal, health care provider-based data from EHR systems across multiple US states and varied pediatric practice types. Our results support the population-level allergic march progression and indicate high rates of comorbidity among children with food and respiratory allergies.</description><subject>Allergic rhinitis</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - drug therapy</subject><subject>Asthma - epidemiology</subject><subject>Atopic dermatitis</subject><subject>Child</subject><subject>Children</subject><subject>Comorbidity</subject><subject>Dermatitis, Atopic - diagnosis</subject><subject>Dermatitis, Atopic - epidemiology</subject><subject>Diagnosis</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Eosinophilic Esophagitis - diagnosis</subject><subject>Eosinophilic Esophagitis - epidemiology</subject><subject>Epidemiology</subject><subject>Esophagitis</subject><subject>Food allergies</subject><subject>Food Hypersensitivity - diagnosis</subject><subject>Humans</subject><subject>Immunoglobulin E</subject><subject>Infant</subject><subject>Leukocytes (eosinophilic)</subject><subject>Pediatrics</subject><subject>Rhinitis, Allergic - epidemiology</subject><issn>0031-4005</issn><issn>1098-4275</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkctLxDAQh4Mouj7unqTgxUvXyaNNchJZn7DgHvQcssnUrfRl0l3wv7dlVdTTHOb7_ZjhI-SUwpRmgl126OOUAWMp5JBxukMmFLRKBZPZLpkAcJoKgOyAHMb4BgAik2yfHHAplGYqnxBY2L7H0MSkbJJ-hckNbrBquxqbPmmLZIG-tH0oXXJdVRheP47JXmGriCdf84i83N0-zx7S-dP94-x6njqhaZ8uPVe5VVS5QmcUUCvqnLYInmHhC0cVpT4rpHacW-sV-KXEXC61cJxJD_yIXG17u_WyRu-Ge4KtTBfK2oYP09rS_N005cq8thtDgSstpRgaLr4aQvu-xtibuowOq8o22K6jYUpQJbXi2YCe_0Pf2nVohv9GKmeacz1SsKVcaGMMWPxcQ8GMPszow4w-zNbHEDn7_cVP4FsA_wS4fobC</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Gabryszewski, Stanislaw J</creator><creator>Dudley, Jesse</creator><creator>Shu, Di</creator><creator>Faerber, Jennifer A</creator><creator>Grundmeier, Robert W</creator><creator>Fiks, Alexander G</creator><creator>Hill, David A</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230801</creationdate><title>Patterns in the Development of Pediatric Allergy</title><author>Gabryszewski, Stanislaw J ; Dudley, Jesse ; Shu, Di ; Faerber, Jennifer A ; Grundmeier, Robert W ; Fiks, Alexander G ; Hill, David A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-bd386a818cf9510e981cc9ae0d2efdfc1811d5f79c33aad80db7e67b94c327d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergic rhinitis</topic><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - drug therapy</topic><topic>Asthma - epidemiology</topic><topic>Atopic dermatitis</topic><topic>Child</topic><topic>Children</topic><topic>Comorbidity</topic><topic>Dermatitis, Atopic - diagnosis</topic><topic>Dermatitis, Atopic - epidemiology</topic><topic>Diagnosis</topic><topic>Electronic health records</topic><topic>Electronic medical records</topic><topic>Eosinophilic Esophagitis - diagnosis</topic><topic>Eosinophilic Esophagitis - epidemiology</topic><topic>Epidemiology</topic><topic>Esophagitis</topic><topic>Food allergies</topic><topic>Food Hypersensitivity - diagnosis</topic><topic>Humans</topic><topic>Immunoglobulin E</topic><topic>Infant</topic><topic>Leukocytes (eosinophilic)</topic><topic>Pediatrics</topic><topic>Rhinitis, Allergic - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabryszewski, Stanislaw J</creatorcontrib><creatorcontrib>Dudley, Jesse</creatorcontrib><creatorcontrib>Shu, Di</creatorcontrib><creatorcontrib>Faerber, Jennifer A</creatorcontrib><creatorcontrib>Grundmeier, Robert W</creatorcontrib><creatorcontrib>Fiks, Alexander G</creatorcontrib><creatorcontrib>Hill, David A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabryszewski, Stanislaw J</au><au>Dudley, Jesse</au><au>Shu, Di</au><au>Faerber, Jennifer A</au><au>Grundmeier, Robert W</au><au>Fiks, Alexander G</au><au>Hill, David A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns in the Development of Pediatric Allergy</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>152</volume><issue>2</issue><spage>1</spage><pages>1-</pages><issn>0031-4005</issn><issn>1098-4275</issn><eissn>1098-4275</eissn><abstract>Describe clinical and epidemiologic patterns of pediatric allergy using longitudinal electronic health records (EHRs) from a multistate consortium of US practices.
Using the multistate Comparative Effectiveness Research through Collaborative Electronic Reporting EHR database, we defined a cohort of 218 485 children (0-18 years) who were observed for ≥5 years between 1999 and 2020. Children with atopic dermatitis (AD), immunoglobulin E-mediated food allergy (IgE-FA), asthma, allergic rhinitis (AR), and eosinophilic esophagitis (EoE) were identified using a combination of diagnosis codes and medication prescriptions. We determined age at diagnosis, cumulative incidence, and allergic comorbidity.
Allergic disease cumulative (and peak age of) incidence was 10.3% (4 months) for AD, 4.0% (13 months) for IgE-FA, 20.1% (13 months) for asthma, 19.7% (26 months) for AR, and 0.11% (35 months) for EoE. The most diagnosed IgE-FAs were peanut (1.9%), egg (0.8%), and shellfish (0.6%). A total of 13.4% of children had ≥2 allergic conditions, and respiratory allergies (ie, asthma, AR) were commonly comorbid with each other, and with other allergic conditions.
We detail pediatric allergy patterns using longitudinal, health care provider-based data from EHR systems across multiple US states and varied pediatric practice types. Our results support the population-level allergic march progression and indicate high rates of comorbidity among children with food and respiratory allergies.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>37489286</pmid><doi>10.1542/peds.2022-060531</doi><oa>free_for_read</oa></addata></record> |
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subjects | Allergic rhinitis Asthma Asthma - diagnosis Asthma - drug therapy Asthma - epidemiology Atopic dermatitis Child Children Comorbidity Dermatitis, Atopic - diagnosis Dermatitis, Atopic - epidemiology Diagnosis Electronic health records Electronic medical records Eosinophilic Esophagitis - diagnosis Eosinophilic Esophagitis - epidemiology Epidemiology Esophagitis Food allergies Food Hypersensitivity - diagnosis Humans Immunoglobulin E Infant Leukocytes (eosinophilic) Pediatrics Rhinitis, Allergic - epidemiology |
title | Patterns in the Development of Pediatric Allergy |
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