Cellular polyploidy in organ homeostasis and regeneration

Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellul...

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Bibliographic Details
Published in:Protein & cell 2023-08, Vol.14 (8), p.560-578
Main Authors: Fang, Juntao, Bruin, Alain de, Villunger, Andreas, Schiffelers, Raymond, Lei, Zhiyong, Sluijter, Joost P.G.
Format: Article
Language:English
Subjects:
cardiac regeneration
Cell Cycle
cellular polyploidy
Hepatocytes
Homeostasis
Humans
Liver
liver regeneration
Polyploidy
Review
tissue regeneration
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Summary:Polyploid cells, which contain more than one set of chromosome pairs, are very common in nature. Polyploidy can provide cells with several potential benefits over their diploid counterparts, including an increase in cell size, contributing to organ growth and tissue homeostasis, and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals. Here, we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid. Moreover, we discuss its crucial roles in cell growth and tissue regeneration in the heart, liver, and other tissues.
ISSN:1674-800X
1674-8018
DOI:10.1093/procel/pwac064