Anti-glomerular basement membrane disease developing 3 years after the development of Sweet syndrome and 1 year after the development of anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report

• Published in: CEN case reports 2023-08, Vol.12 (3), p.259-264
• Main Authors: Matsuno, Shiho, Itabashi, Mitsuyo, Komatsu, Akiko, Taito, Kenta, Izawa, Ayano, Tsuchiya, Takaaki, Yamanaka, Noriko, Oka, Masatoshi, Yumura, Wako, Arai, Tomio, Takei, Takashi
• Format: Article
• Language: English
• Subjects: Aged; Anti-Glomerular Basement Membrane Disease - complications; Anti-Glomerular Basement Membrane Disease - diagnosis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis; Antibodies, Antineutrophil Cytoplasmic; Case Report; Female; Glomerulonephritis; Humans; Medicine; Medicine & Public Health; Nephrology; Sweet Syndrome - complications; Sweet Syndrome - diagnosis; Urology
• ISSN: 2192-4449; 2192-4449
• DOI: 10.1007/s13730-022-00758-3

A 73-year-old Japanese woman, with a history of Sweet syndrome diagnosed 3 years earlier and anti-myeloperoxidase (MPO) antibody anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis diagnosed 1 year earlier, presented with an episode of rapidly progressive glomerulonephritis (RPGN) with anti-glomerular basement membrane (GBM) disease. At the time of diagnosis of the ANCA-associated vasculitis 1 year earlier, serological testing yielded a negative result for anti-GBM antibody. However, at the present visit, serology for anti-MPO antibody was negative, while that for anti-GBM antibody was positive. This is the first report of anti-GBM disease developing sequentially after Sweet syndrome and ANCA-associated vasculitis. This case may provide clues to the potential immunological links among these three distinct conditions.