Immunoglobulin G4-related Hepatopathy after COVID-19 Vaccination

An 84-year-old woman with IgG4-related disease presented with jaundice and liver dysfunction after coronavirus disease 2019 (COVID-19) vaccination. Serum IgG4 levels were elevated. Diagnostic imaging showed no stenotic lesions in the bile ducts. A liver biopsy was performed because of the enlarged l...

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Bibliographic Details
Published in:Internal Medicine 2023/07/15, Vol.62(14), pp.2139-2143
Main Authors: Kuno, Masahiro, Sawa, Naoki, Mizuno, Hiroki, Oba, Yuki, Ikuma, Daisuke, Sekine, Akinari, Yamanouchi, Masayuki, Hasegawa, Eiko, Suwabe, Tatsuya, Saito, Satoshi, Kono, Kei, Kinowaki, Keiichi, Notohara, Kenji, Ubara, Yoshifumi
Format: Article
Language:English
Subjects:
Aged, 80 and over
Bile ducts
Biopsy
Case Report
Coronaviruses
COVID-19
COVID-19 - prevention & control
COVID-19 vaccination
COVID-19 Vaccines - adverse effects
Female
Hepatitis
Humans
IgG4-related hepatopathy
Immunoglobulin G
Immunoglobulin G4
Immunoglobulin G4-Related Disease - pathology
Infiltration
Inflammation
Internal medicine
Jaundice
Liver diseases
Liver Diseases - etiology
Plasma cells
Remission
Vaccination
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Description
Summary:An 84-year-old woman with IgG4-related disease presented with jaundice and liver dysfunction after coronavirus disease 2019 (COVID-19) vaccination. Serum IgG4 levels were elevated. Diagnostic imaging showed no stenotic lesions in the bile ducts. A liver biopsy was performed because of the enlarged liver. Infiltration of IgG4-positive plasma cells, which accounted for approximately 74% of total plasma cells, was found in the portal area, but there was no evidence of periportal hepatitis, and inflammatory cell infiltration into the lobular space was minimal. IgG4-related hepatopathy was diagnosed. The patient achieved spontaneous remission with no treatment and only follow-up and remains under observation at the time of writing.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1634-23