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Increased hippocampal efficiency is associated with greater headache frequency in adolescents with chronic headache

Abstract Adults with chronic headache have altered brain hippocampal efficiency networks. Less is known about the mechanisms underlying chronic headache in youth. In total, 29 youth with chronic headache (10–18 years), and 29 healthy, age- and sex-matched controls tracked their headache attacks dail...

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Bibliographic Details
Published in:Cerebral cortex communications 2023-07, Vol.4 (3), p.tgad013-tgad013
Main Authors: Cobos, Karen L, Long, Xiangyu, Lebel, Catherine, Rasic, Nivez, Noel, Melanie, Miller, Jillian V
Format: Article
Language:English
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Summary:Abstract Adults with chronic headache have altered brain hippocampal efficiency networks. Less is known about the mechanisms underlying chronic headache in youth. In total, 29 youth with chronic headache (10–18 years), and 29 healthy, age- and sex-matched controls tracked their headache attacks daily for 1-month period. Following this, they underwent a resting state functional magnetic resonance imaging scan and self-reported on their pubertal status, post-traumatic stress, anxiety, and depression symptoms. Graph-based topological analyses of brain networks, rendering hippocampal efficiency values were performed. T-tests were used to compare hippocampal efficiency metrics between patients and controls. Linear regression was used to examine significant hippocampal efficiency metrics in relation to headache frequency in patients, controlling for age, sex, pubertal status, post-traumatic stress, anxiety, and depression symptoms. Patients had higher right hippocampal global efficiency, shorter right hippocampal path length, and higher right hippocampal clustering coefficient compared to controls (P 
ISSN:2632-7376
2632-7376
DOI:10.1093/texcom/tgad013