Resolving the Mechanism for H2O2 Decomposition over Zr(IV)-Substituted Lindqvist Tungstate: Evidence of Singlet Oxygen Intermediacy

• Published in: ACS catalysis 2023-08, Vol.13 (15), p.10324-10339
• Main Authors: Maksimchuk, Nataliya V., Puiggalí-Jou, Jordi, Zalomaeva, Olga V., Larionov, Kirill P., Evtushok, Vasilii Yu, Soshnikov, Igor E., Solé-Daura, Albert, Kholdeeva, Oxana A., Poblet, Josep M., Carbó, Jorge J.
• Format: Article
• Language: English
• ISSN: 2155-5435; 2155-5435
• DOI: 10.1021/acscatal.3c02416

The decomposition of hydrogen peroxide (H2O2) is the main undesired side reaction in catalytic oxidation processes of industrial interest that make use of H2O2 as a terminal oxidant, such as the epoxidation of alkenes. However, the mechanism responsible for this reaction is still poorly understood, thus hindering the development of design rules to maximize the efficiency of catalytic oxidations in terms of product selectivity and oxidant utilization efficiency. Here, we thoroughly investigated the H2O2 decomposition mechanism using a Zr-monosubstituted dimeric Lindqvist tungstate, (Bu4N)6[{W5O18Zr­(μ-OH)}2] ({ZrW 5 } 2 ), which revealed high activity for this reaction in acetonitrile. The mechanism of the {ZrW 5 } 2 -catalyzed H2O2 degradation in the absence of an organic substrate was investigated using kinetic, spectroscopic, and computational tools. The reaction is first order in the Zr catalyst and shows saturation behavior with increasing H2O2 concentration. The apparent activation energy is 11.5 kcal·mol–1, which is significantly lower than the values previously found for Ti- and Nb-substituted Lindqvist tungstates (14.6 and 16.7 kcal·mol–1, respectively). EPR spectroscopic studies indicated the formation of superoxide radicals, while EPR with a specific singlet oxygen trap, 2,2,6,6-tetramethyl­piperidone (4-oxo-TEMP), revealed the generation of 1O2. The interaction of test substrates, α-terpinene and tetramethylethylene, with H2O2 in the presence of {ZrW 5 } 2 corroborated the formation of products typical of the oxidation processes that engage 1O2 (endoperoxide ascaridole and 2,3-dimethyl-3-butene-2-hydroperoxide, respectively). While radical scavengers t BuOH and p-benzoquinone produced no effect on the peroxide product yield, the addition of 4-oxo-TEMP significantly reduced it. After optimization of the reaction conditions, a 90% yield of ascaridole was attained. DFT calculations provided an atomistic description of the H2O2 decomposition mechanism by Zr-substituted Lindqvist tungstate catalysts. Calculations showed that the reaction proceeds through a Zr-trioxidane [Zr-η2-OO­(OH)] key intermediate, whose formation is the rate-determining step. The Zr-substituted POM activates heterolytically a first H2O2 molecule to generate a Zr-peroxo species, which attacks nucleophilically to a second H2O2, causing its heterolytic O–O cleavage to yield the Zr-trioxidane complex. In agreement with spectroscopic and kinetic studies, the lowest-energy pathway in