The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence

Chemokines are immune system mediators that mediate various activities and play a role in the pathogenesis of several cancers. Among these chemokines, C-X-C motif chemokine 17 (CXCL-17) is a relatively novel molecule produced along the airway epithelium in physiological and pathological conditions,...

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Bibliographic Details
Published in:Journal of cell communication and signaling 2023-09, Vol.17 (3), p.409-422
Main Authors: Hashemi, Seyyede Fatemeh, Khorramdelazad, Hossein
Format: Article
Language:English
Subjects:
Angiogenesis
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer therapies
Cell Biology
Chemokine
Chemokines
CXCL17
CXCR8
Epithelium
Immune system
Life Sciences
Liver cancer
Lung cancer
Malignancy
Myeloid cells
Pathogenesis
Review
Tumors
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Summary:Chemokines are immune system mediators that mediate various activities and play a role in the pathogenesis of several cancers. Among these chemokines, C-X-C motif chemokine 17 (CXCL-17) is a relatively novel molecule produced along the airway epithelium in physiological and pathological conditions, and evidence shows that it plays a homeostatic role in most cases. CXCL17 has a protective role in some cancers and a pathological role in others, such as liver and lung cancer. This chemokine, along with its possible receptor termed G protein-coupled receptor 35 (GPR35) or CXCR8, are involved in recruiting myeloid cells, regulating angiogenesis, defending against pathogenic microorganisms, and numerous other mechanisms. Considering the few studies that have been performed on the dual role of CXCL17 in human malignancies, this review has investigated the possible pro-tumor and anti-tumor roles of this chemokine, as well as future treatment options in cancer therapy. Graphical Abstract
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-022-00699-7