Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies

Hepatic fibrosis is the common pathological change that occurs due to increased synthesis and accumulation of extracellular matrix components. Chronic insult from hepatotoxicants leads to liver cirrhosis, which if not reversed timely using appropriate therapeutics, liver transplantation remains the...

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Bibliographic Details
Published in:Journal of cell communication and signaling 2023-09, Vol.17 (3), p.549-561
Main Authors: Mekala, Sowmya, Dugam, Prachi, Das, Amitava
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cholangiocarcinoma
Cirrhosis
Developmental stages
Diabetes mellitus
Drug development
Eph RTKs
Ephrins
Extracellular matrix
Fibrosis
Hepatic fibrosis
Hepatocellular carcinoma
Life Sciences
Liver diseases
Liver transplantation
NAFLD
Pathology
Phenotypes
Review
Tyrosine
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Summary:Hepatic fibrosis is the common pathological change that occurs due to increased synthesis and accumulation of extracellular matrix components. Chronic insult from hepatotoxicants leads to liver cirrhosis, which if not reversed timely using appropriate therapeutics, liver transplantation remains the only effective therapy. Often the disease further progresses into hepatic carcinoma. Although there is an increased advancement in understanding the pathological phenotypes of the disease, additional knowledge of the novel molecular signaling mechanisms involved in the disease progression would enable the development of efficacious therapeutics. Ephrin–Eph molecules belong to the largest family of receptor tyrosine kinases (RTKs) which are identified to play a crucial role in cellular migratory functions, during morphological and developmental stages. Additionally, they contribute to the growth of a multicellular organism as well as in pathological conditions like cancer, and diabetes. A wide spectrum of mechanistic studies has been performed on ephrin–Eph RTKs in various hepatic tissues under both normal and diseased conditions revealing their diverse roles in hepatic pathology. This systematic review summarizes the liver-specific ephrin–Eph RTK signaling mechanisms and recognizes them as druggable targets for mitigating hepatic pathology. Graphical abstract
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-023-00750-1