Biological functions of CRTC2 and its role in metabolism-related diseases

CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element bindin...

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Bibliographic Details
Published in:Journal of cell communication and signaling 2023-09, Vol.17 (3), p.495-506
Main Authors: Zheng, Hong-Yu, Wang, Yan-Xia, Zhou, Kun, Xie, Hai-Lin, Ren, Zhong, Liu, Hui-Ting, Ou, Yang-Shao, Zhou, Zhi-Xiang, Jiang, Zhi-Sheng
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
CRTC2
Cyclic AMP response element-binding protein
Cytoplasm
Energy metabolism
Glucose metabolism
Homeostasis
Life Sciences
Lipid metabolism
Phosphorylation
Protein turnover
Rapamycin
Review
Signal transduction
Sterol regulatory element-binding protein
TOR protein
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Summary:CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element binding protein 1(SREBP1), Sterol regulatory element binding protein 2 (SREBP2) and other substances Current studies on CRTC2 mainly focus on glucose and lipid metabolism, relevant studies show that CRTC2 can participate in the occurrence and development of related diseases by affecting metabolic homeostasis. It has been found that Crtc2 acts as a signaling regulator for cAMP and Ca2 + signaling pathways in many cell types, and phosphorylation at ser171 and ser275 can regulate downstream biological functions by controlling CRTC2 shuttling between cytoplasm and nucleus. Graphical abstract
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-023-00730-5