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Biological functions of CRTC2 and its role in metabolism-related diseases
CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element bindin...
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| Published in: | Journal of cell communication and signaling 2023-09, Vol.17 (3), p.495-506 |
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| container_end_page | 506 |
| container_issue | 3 |
| container_start_page | 495 |
| container_title | Journal of cell communication and signaling |
| container_volume | 17 |
| creator | Zheng, Hong-Yu Wang, Yan-Xia Zhou, Kun Xie, Hai-Lin Ren, Zhong Liu, Hui-Ting Ou, Yang-Shao Zhou, Zhi-Xiang Jiang, Zhi-Sheng |
| description | CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element binding protein 1(SREBP1), Sterol regulatory element binding protein 2 (SREBP2) and other substances Current studies on CRTC2 mainly focus on glucose and lipid metabolism, relevant studies show that CRTC2 can participate in the occurrence and development of related diseases by affecting metabolic homeostasis. It has been found that Crtc2 acts as a signaling regulator for cAMP and Ca2 + signaling pathways in many cell types, and phosphorylation at ser171 and ser275 can regulate downstream biological functions by controlling CRTC2 shuttling between cytoplasm and nucleus.
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| doi_str_mv | 10.1007/s12079-023-00730-5 |
| format | article |
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Graphical abstract</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>CRTC2</subject><subject>Cyclic AMP response element-binding protein</subject><subject>Cytoplasm</subject><subject>Energy metabolism</subject><subject>Glucose metabolism</subject><subject>Homeostasis</subject><subject>Life Sciences</subject><subject>Lipid metabolism</subject><subject>Phosphorylation</subject><subject>Protein turnover</subject><subject>Rapamycin</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Sterol regulatory element-binding protein</subject><subject>TOR protein</subject><issn>1873-9601</issn><issn>1873-961X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNUU1rFTEUDaLYL_-ACwm4cTOaj8kkwYW0Q6uFgqAtuAuZzJ1nSmZSkxml_948pz6tiyJZJJecc-45HISeU_KaEiLfZMqI1BVhvCojJ5V4hPapkrzSDf3yePcmdA8d5HxNiJCC0adojzdKNJrpfXR-4mOIG-9swMMyudnHKeM44PbTZcuwnXrs54xTDID9hEeYbReDz2OVINgZetz7DDZDPkJPBhsyPLu7D9HV2ell-6G6-Pj-vD2-qFwtFasGKqWCDqTSyvXl0KaMVOmaSQJd3XMqBitrZ63kNaedFlQA7cDVgjed5Ifo3ap7s3Qj9A6mOdlgbpIfbbo10Xpz_2fyX80mfjeU1ERryYvCqzuFFL8tkGcz-uwgBDtBXLJhUlFGa8K2y17-A72OS5pKPsNUySO41KKg2IpyKeacYNi5ocRsqzJrVaZUZX5VZbakF3_n2FF-d1MAb1fADx_g9j8kTdt-5idnZRKssPnKzoU4bSD9cf6AqZ9q46_S</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Zheng, Hong-Yu</creator><creator>Wang, Yan-Xia</creator><creator>Zhou, Kun</creator><creator>Xie, Hai-Lin</creator><creator>Ren, Zhong</creator><creator>Liu, Hui-Ting</creator><creator>Ou, Yang-Shao</creator><creator>Zhou, Zhi-Xiang</creator><creator>Jiang, Zhi-Sheng</creator><general>Springer Netherlands</general><general>John Wiley & Sons, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5685-6228</orcidid></search><sort><creationdate>202309</creationdate><title>Biological functions of CRTC2 and its role in metabolism-related diseases</title><author>Zheng, Hong-Yu ; Wang, Yan-Xia ; Zhou, Kun ; Xie, Hai-Lin ; Ren, Zhong ; Liu, Hui-Ting ; Ou, Yang-Shao ; Zhou, Zhi-Xiang ; Jiang, Zhi-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-f1778ebe7898cdcdc168eb1894270eb4d315fa74caa73431b9515e1bec4536b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>CRTC2</topic><topic>Cyclic AMP response element-binding protein</topic><topic>Cytoplasm</topic><topic>Energy metabolism</topic><topic>Glucose metabolism</topic><topic>Homeostasis</topic><topic>Life Sciences</topic><topic>Lipid metabolism</topic><topic>Phosphorylation</topic><topic>Protein turnover</topic><topic>Rapamycin</topic><topic>Review</topic><topic>Signal transduction</topic><topic>Sterol regulatory element-binding protein</topic><topic>TOR protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Hong-Yu</creatorcontrib><creatorcontrib>Wang, Yan-Xia</creatorcontrib><creatorcontrib>Zhou, Kun</creatorcontrib><creatorcontrib>Xie, Hai-Lin</creatorcontrib><creatorcontrib>Ren, Zhong</creatorcontrib><creatorcontrib>Liu, Hui-Ting</creatorcontrib><creatorcontrib>Ou, Yang-Shao</creatorcontrib><creatorcontrib>Zhou, Zhi-Xiang</creatorcontrib><creatorcontrib>Jiang, Zhi-Sheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cell communication and signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Hong-Yu</au><au>Wang, Yan-Xia</au><au>Zhou, Kun</au><au>Xie, Hai-Lin</au><au>Ren, Zhong</au><au>Liu, Hui-Ting</au><au>Ou, Yang-Shao</au><au>Zhou, Zhi-Xiang</au><au>Jiang, Zhi-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological functions of CRTC2 and its role in metabolism-related diseases</atitle><jtitle>Journal of cell communication and signaling</jtitle><stitle>J. Cell Commun. Signal</stitle><addtitle>J Cell Commun Signal</addtitle><date>2023-09</date><risdate>2023</risdate><volume>17</volume><issue>3</issue><spage>495</spage><epage>506</epage><pages>495-506</pages><issn>1873-9601</issn><eissn>1873-961X</eissn><abstract>CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element binding protein 1(SREBP1), Sterol regulatory element binding protein 2 (SREBP2) and other substances Current studies on CRTC2 mainly focus on glucose and lipid metabolism, relevant studies show that CRTC2 can participate in the occurrence and development of related diseases by affecting metabolic homeostasis. It has been found that Crtc2 acts as a signaling regulator for cAMP and Ca2 + signaling pathways in many cell types, and phosphorylation at ser171 and ser275 can regulate downstream biological functions by controlling CRTC2 shuttling between cytoplasm and nucleus.
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| ispartof | Journal of cell communication and signaling, 2023-09, Vol.17 (3), p.495-506 |
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| source | Springer Nature; PubMed Central |
| subjects | Biomedical and Life Sciences Biomedicine Cell Biology CRTC2 Cyclic AMP response element-binding protein Cytoplasm Energy metabolism Glucose metabolism Homeostasis Life Sciences Lipid metabolism Phosphorylation Protein turnover Rapamycin Review Signal transduction Sterol regulatory element-binding protein TOR protein |
| title | Biological functions of CRTC2 and its role in metabolism-related diseases |
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