Short term cyclosporin A treatment of Behçet's disease

Eleven separate three-month courses of cyclosporin A, an oral solution 10 mg/kg/day, were administered to eight patients with Behçet's disease with sight-threatening posterior uveitis. It was found to be effective in arresting the inflammatory activity in the eye as well as the mucocutaneous le...

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Bibliographic Details
Published in:British journal of ophthalmology 1987-05, Vol.71 (5), p.387-390
Main Authors: Müftüoğlu, A U, Pazarli, H, Yurdakul, S, Yazici, H, Ulkü, B Y, Tüzün, Y, Serdaroğlu, S, Altuğ, E, Bahçecioğlu, H, Güngen, G
Format: Article
Language:English
Subjects:
Adult
Behcet Syndrome - drug therapy
Biological and medical sciences
Cyclosporins - administration & dosage
Cyclosporins - adverse effects
Cyclosporins - therapeutic use
Female
Hirsutism - chemically induced
Humans
Immunomodulators
Male
Medical sciences
Pharmacology. Drug treatments
Skin Tests
Substance Withdrawal Syndrome
Uveitis - drug therapy
Visual Acuity
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Summary:Eleven separate three-month courses of cyclosporin A, an oral solution 10 mg/kg/day, were administered to eight patients with Behçet's disease with sight-threatening posterior uveitis. It was found to be effective in arresting the inflammatory activity in the eye as well as the mucocutaneous lesions of Behçet's disease. Improvement in visual acuity was observed within one week of starting therapy. Severe exacerbations in the ocular and mucocutaneous lesions occurred on withdrawal of the drug. At this dosage side effects included hirsutism in all women, and a slight rise of serum bilirubins in two patients and of blood urea in one patient. The latter two conditions responded rapidly to dose adjustment.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.71.5.387