Biomarkers of exposure and potential harm in exclusive users of electronic cigarettes and current, former, and never smokers

Electronic cigarette (EC) aerosol emissions generally contain fewer and lower concentrations of harmful and potentially harmful constituents, compared with cigarette smoke. Further studies are needed to establish whether decreased emissions translate to reduced health risks for EC users. In a cross-...

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Bibliographic Details
Published in:Internal and emergency medicine 2023-08, Vol.18 (5), p.1359-1371
Main Authors: Haswell, Linsey E., Gale, Nathan, Brown, Elaine, Azzopardi, David, McEwan, Michael, Thissen, Jesse, Meichanetzidis, Filimon, Hardie, George
Format: Article
Language:English
Subjects:
Biomarkers
Carbon monoxide
Cell adhesion
Cigarette smoke
Cigarettes
Cotinine
Cross-Sectional Studies
Electronic cigarettes
Electronic Nicotine Delivery Systems
Emissions
Health Impact of Electronic Cigarettes and Tobacco Heating Systems
Humans
Im - Original
Intercellular adhesion molecule 1
Internal Medicine
Medicine
Medicine & Public Health
Nicotiana
Oxidative stress
Smokers
Smoking
Tobacco
Tobacco Products
Toxicants
Valine
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Summary:Electronic cigarette (EC) aerosol emissions generally contain fewer and lower concentrations of harmful and potentially harmful constituents, compared with cigarette smoke. Further studies are needed to establish whether decreased emissions translate to reduced health risks for EC users. In a cross-sectional study, biomarkers of exposure (BoE) to certain tobacco smoke toxicants and biomarkers of potential harm (BoPH), associated with biological processes linked to the potential development of smoking-related diseases and oxidative stress, were assessed in solus Vuse ECs users and current, former, and never smokers. In total, 213 participants were enrolled, and smoking status was confirmed by urinary cotinine, exhaled carbon monoxide, and N-(2-cyanoethyl)valine levels (EC users and former smokers only). During confinement participants used their usual product (EC or cigarette) as normal and BoE and BoPHs were assessed via blood, 24-h urine, and physiological assessment. Significantly lower levels of all urinary BoE; MHBMA, HMPMA, 3-HPMA, NNN, 3-OH-B[a]P, S-PMA, NNAL (all p  
ISSN:1828-0447
1970-9366
DOI:10.1007/s11739-023-03294-9