Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (BW B759U)

Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual fu...

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Bibliographic Details
Published in:British journal of ophthalmology 1988-07, Vol.72 (7), p.525-529
Main Authors: Orellana, J, Teich, S A, Winterkorn, J S, Mathur-Wagh, U, Handwerger, S, Schlamm, H, Malamud, S C, Yancovitz, S R, Cederberg, D M, Mildvan, D S
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Acyclovir - adverse effects
Acyclovir - analogs & derivatives
Acyclovir - therapeutic use
Adult
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
Biological and medical sciences
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - drug therapy
Eye
Female
Fundus Oculi
Ganciclovir
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Retinitis - complications
Retinitis - drug therapy
Visual Acuity
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Summary:Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.72.7.525