Effect of the use of platelet concentrates on new bone formation in alveolar ridge preservation: a systematic review, meta-analysis, and trial sequential analysis

Objectives To investigate the histomorphometric changes occurring in alveolar ridge preservation (ARP) based on the use of different plasma concentrates (PCs) in randomized clinical trials (RCT). There is controversy whether the placement of PCs in ARP is effective in the formation of new bone. Mate...

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Published in:Clinical oral investigations 2023-08, Vol.27 (8), p.4131-4146
Main Authors: Caponio, Vito Carlo Alberto, Baca-González, Laura, González-Serrano, José, Torres, Jesús, López-Pintor, Rosa María
Format: Article
Language:English
Subjects:
Alveolar bone
Bone growth
Bone healing
Clinical trials
Dentistry
Fibrin
Medicine
Meta-analysis
Osteogenesis
Patients
Platelets
Review
Systematic review
Teeth
Tooth extractions
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Summary:Objectives To investigate the histomorphometric changes occurring in alveolar ridge preservation (ARP) based on the use of different plasma concentrates (PCs) in randomized clinical trials (RCT). There is controversy whether the placement of PCs in ARP is effective in the formation of new bone. Materials and methods A systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICO question: In patients undergoing tooth extraction followed by ARP, do PCs alone in the post-extraction socket in comparison with spontaneous healing improve new vital bone formation percentage in histomorphometric analysis after more than 10 weeks? The risk of bias was assessed and a meta-analysis was conducted. Results Of 3809 results, 8 studies were considered suitable for inclusion. A total of 255 teeth were extracted in 250 patients. Regarding the PCs used, ARP was performed with platelet- and leukocyte-rich fibrin (L-PRF) in 120 sockets, and with pure platelet-rich plasma (P-PRP) in 31 sockets and 104 sockets were controlled. PCs improved new bone formation in ARP with respect to the spontaneous healing group (SMD = 1.77, 95%C.I. = 1.47–2.06, p -value 
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-023-05126-8