Synthesis, Solid State Structure, and Cytotoxic Activity of a Complex Dimer of Yttrium with Anthranilic Acid against Cancer Cells

• Published in: Biological trace element research 2023-10, Vol.201 (10), p.4688-4696
• Main Authors: Zidan, Amna S. A., Ibrahim, Ahmed B. M., Aly, Aref A. M., Mosbah, Hanan K., Mayer, Peter, Saber, Saber H.
• Format: Article
• Language: English
• Subjects: Acids; Anthranilic acid; Antineoplastic Agents - chemistry; Biochemistry; Biomedical and Life Sciences; Biotechnology; Bladder; Bladder cancer; Breast cancer; Cancer; Cancer therapies; Cell Line, Tumor; Cells; Chloride; Chloride ions; Crystals; Cytotoxicity; Humans; Ions; Life Sciences; Ligands; Lymphoma; Molecular structure; NMR; Nuclear magnetic resonance; Nutrition; Oncology; ortho-Aminobenzoates - pharmacology; Prostate cancer; Single crystals; Software packages; Synthesis; Urinary Bladder Neoplasms; X ray analysis; X-ray spectroscopy; Yttrium
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-022-03545-4

This paper presents the synthesis and isolation of a new binuclear complex of yttrium with anthranilic acid (HA). The complex [Y 2 (HA) 6 (H 2 O) 4 ] Cl 6 .2C 2 H 5 OH ( C1 ) was obtained as single crystals that its X-ray analysis revealed its triclinic P-1 space group in addition to anti-prismatic geometry around each of the yttrium ions. In the complex, the anthranilic acid ligands are bidentate, zwitter ionic and neutral, and the yttrium ions’ charge is only compensated by six chloride ions. The cytotoxicity of this complex against human breast cancer MDA-MB-231 cells, prostate cancer PC-3 cells, and bladder cancer T-24 cells was evaluated. This yttrium complex displayed more cytotoxic activity against the bladder cancer cells with an IC 50 value of 307.7 μg/ml (223 μM). On the other hand, the activities of complex C1 against the MDA-MB-231 and PC-3 cells were less significant respectively with IC 50 values of 1097 μg/ml (796 μM) and 921 μg/ml (669 μM).