Impact on glucometric variables and quality of life of the advanced hybrid closed-loop system in pediatric and adolescent type 1 diabetes

• Published in: Journal of diabetes 2023-08, Vol.15 (8), p.699-708
• Main Authors: Lendínez-Jurado, Alfonso, Gómez-Perea, Ana, Ariza-Jiménez, Ana B, Tapia-Ceballos, Leopoldo, Becerra-Paz, Icía, Martos-Lirio, María F, Moreno-Jabato, Fernando, Leiva-Gea, Isabel
• Format: Article
• Language: English
• Subjects: Automation; Diabetes; Hyperglycemia; Original; Pediatrics; Quality of life; Teenagers
• ISSN: 1753-0393; 1753-0407
• DOI: 10.1111/1753-0407.13426

In recent years, technological advances in the field of diabetes have revolutionized the management, prognosis, and quality of life of diabetes patients and their environment. The aim of our study was to evaluate the impact of implementing the MiniMed 780G closed-loop system in a pediatric and adolescent population previously treated with a continuous subcutaneous insulin infusion pump and intermittent glucose monitoring. Data were collected from 28 patients with type 1 diabetes aged 6 to 17 years, with a follow-up of 6 months. We included both glucometric and quality of life variables, as well as quality of life in primary caregivers. Metabolic control variables were assessed at baseline (before system change) and at different cutoff points after initiation of the closed-loop system (48 hours, 7 days, 14 days, 21 days, 1 month, 3 months, 6 months). Time in range 70-180 mg/dL increased from 59.44% at baseline to 74.29% in the first 48 hours after automation of the new system, and this improvement was maintained at the other cutoff points, as was time in hyperglycemia 180-250 mg/dL (24.44% at baseline to 18.96% at 48 hours) and >250 mg/dL (11.71% at baseline to 3.82% at 48 hours). Our study showed an improvement in time in range and in all time spent in hyperglycemia from the first 48 hours after the automation of the system, which was maintained at 6 months.