Aloe-Emodin Ameliorates Cecal Ligation and Puncture-Induced Sepsis

Sepsis remains a major challenge owing to its severe adverse effects and high mortality, against which specific pharmacological interventions with high efficacy are limited. Mitigation of hyperactive inflammatory responses is a key factor in enhancing the likelihood of survival in patients with seps...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-07, Vol.24 (15), p.11972
Main Authors: Su, Jingqian, Chen, Siyuan, Xiao, Jianbin, Feng, Zhihua, Hu, Shan, Su, Qiaofen, Chen, Qi, Chen, Duo
Format: Article
Language:English
Subjects:
Analysis
Blood
Complications and side effects
Coronaviruses
Cytokines
Cytotoxicity
Discriminant analysis
Health insurance
Heart
Homeostasis
Infection
Infections
Inflammation
Liver
Microbiota
Microbiota (Symbiotic organisms)
Mortality
Sepsis
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Summary:Sepsis remains a major challenge owing to its severe adverse effects and high mortality, against which specific pharmacological interventions with high efficacy are limited. Mitigation of hyperactive inflammatory responses is a key factor in enhancing the likelihood of survival in patients with sepsis. The genus has several health benefits, including anti-inflammatory properties. The toxicological implications of aloe-emodin (AE), extracted from various species, remain uncertain in clinical contexts. However, AE has been shown to inhibit inflammatory responses in lipopolysaccharide-induced mice, indicating its potential as a therapeutic approach for sepsis treatment. Nonetheless, there is a paucity of data regarding the therapeutic benefits of AE in the widely recognized cecal ligation and puncture (CLP)-induced sepsis model, which is commonly used as the gold standard model for sepsis research. This study demonstrates the potential benefits of AE in the treatment of CLP-induced sepsis and investigates its underlying mechanism, along with the efficacy of postoperative AE treatment in mice with CLP-induced sepsis. The results of this study suggest that AE can mitigate sepsis in mice by diminishing systemic inflammation and regulating the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241511972