Photodynamic therapy for colorectal cancer: an update and a look to the future

This review provides an update on the current state of photodynamic therapy (PDT) for colorectal cancer (CRC) and explores potential future directions in this field. PDT has emerged as a promising minimally invasive treatment modality that utilizes photosensitizers and specific light wavelengths to...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-07, Vol.24 (15), p.1-21
Main Authors: Rodrigues, José Artur Oliveira, Correia, J. H.
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Cancer therapies
Care and treatment
Cell death
Colonoscopy
Colorectal cancer
Combination therapies
Cytotoxicity
Health aspects
Light
Light sources
Lymphatic system
Medical prognosis
Nanotechnology
Patients
Photodynamic therapy
Photosensitizers
Polyps
Rectum
Review
Tumors
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Summary:This review provides an update on the current state of photodynamic therapy (PDT) for colorectal cancer (CRC) and explores potential future directions in this field. PDT has emerged as a promising minimally invasive treatment modality that utilizes photosensitizers and specific light wavelengths to induce cell death in targeted tumor tissues. In recent years, significant progress has been made in understanding the underlying mechanisms, optimizing treatment protocols, and improving the efficacy of PDT for CRC. This article highlights key advancements in PDT techniques, including novel photosensitizers, light sources, and delivery methods. Furthermore, it discusses ongoing research efforts and potential future directions, such as combination therapies and nanotechnology-based approaches. By elucidating the current landscape and providing insights into future directions, this review aims to guide researchers and clinicians in harnessing the full potential of PDT for the effective management of CRC. (PTDC/FIS-OTI/1259/2020)
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241512204