Choroidal malignant melanoma in an albino

This is the first report of an amelanotic melanoma arising in the unpigmented choroid of a tyrosinase-positive oculocutaneous albino (TPOCA). Melanosomes within the tumour showed a maturation arrest in the unpigmented type II (premelanosome) phase. Other neural crest derived melanocytes in iris and...

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Bibliographic Details
Published in:British journal of ophthalmology 1989-10, Vol.73 (10), p.840-845
Main Authors: Casswell, A G, McCartney, A C, Hungerford, J L
Format: Article
Language:English
Subjects:
Adult
Albinism - complications
Biological and medical sciences
Choroid Neoplasms - complications
Choroid Neoplasms - pathology
Dermatology
Female
Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue
Humans
Medical sciences
Melanoma - complications
Melanoma - pathology
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Summary:This is the first report of an amelanotic melanoma arising in the unpigmented choroid of a tyrosinase-positive oculocutaneous albino (TPOCA). Melanosomes within the tumour showed a maturation arrest in the unpigmented type II (premelanosome) phase. Other neural crest derived melanocytes in iris and choroid showed similar limited melanogenesis. The neuroectodermally derived melanocytes of the iris, ciliary body, and retinal pigment epithelium (RPE) contained mature melanosomes, though clinically the RPE was pale. The significance of this tumour arising in an albinotic eye is discussed.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.73.10.840