Transient Neonatal Diabetes Mellitus and Seizure with an Unknown Etiology

Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes, usually occurring in the first 6 months of life. Here, we present a newborn, which was admitted with epileptic seizure on the postnatal second day of life. Sepsis and meningitis were ruled out. Cranial imaging and electroencephalograp...

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Published in:Journal of pediatric genetics (Birmingham, Ala.) Ala.), 2023-09, Vol.12 (3), p.242-245
Main Authors: Gunes, Sevinc Odabasi, Calisici, Erhan, Arslan, Mutluay, Akin, Onur, Karagol, Belma Saygili
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Calisici, Erhan
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Karagol, Belma Saygili
description Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes, usually occurring in the first 6 months of life. Here, we present a newborn, which was admitted with epileptic seizure on the postnatal second day of life. Sepsis and meningitis were ruled out. Cranial imaging and electroencephalography revealed normal. She developed transient NDM on the follow-up and was diagnosed to carry an mutation. Although the neurological features are more common in patients with mutations, patients with mutations could also represent with subtle neurodevelopmental changes or even with epileptic seizures. The genetic testing and appropriate therapy is important in this patient group for predicting clinical course and possible additional features.
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title Transient Neonatal Diabetes Mellitus and Seizure with an Unknown Etiology
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