Randomised single blind trial to compare the toxicity of subconjunctival gentamicin and cefuroxime in cataract surgery

Comparatively little attention has been paid to the conjunctival toxicity of antibiotics administered at the time of cataract surgery. We have observed the effect of subconjunctival gentamicin and cefuroxime injection, using colour photography in a randomised single blind trial of 121 patients under...

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Bibliographic Details
Published in:British journal of ophthalmology 1990-12, Vol.74 (12), p.734-738
Main Authors: Jenkins, C D, McDonnell, P J, Spalton, D J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cataract Extraction
Cefuroxime - adverse effects
Conjunctiva - drug effects
Conjunctival Diseases - chemically induced
Drug toxicity and drugs side effects treatment
Edema - chemically induced
Endophthalmitis - prevention & control
Eye Hemorrhage - chemically induced
Gentamicins - adverse effects
Humans
Hyperemia - chemically induced
Intraoperative Care
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Observer Variation
Pharmacology. Drug treatments
Prospective Studies
Single-Blind Method
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Summary:Comparatively little attention has been paid to the conjunctival toxicity of antibiotics administered at the time of cataract surgery. We have observed the effect of subconjunctival gentamicin and cefuroxime injection, using colour photography in a randomised single blind trial of 121 patients undergoing routine cataract surgery. Our results suggest that a hyperaemic eye is likely to occur about twice as often in patients injected with gentamicin (p less than 0.001). Gentamicin is associated with more pain postoperatively (p less than 0.05). Significant manifestations of gentamicin toxicity are conjunctival oedema and capillary closure. Cefuroxime has some theoretical advantages over gentamicin in its antibacterial spectrum.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.74.12.734