Expression of pyroptosis-related genes are correlated with immune microenvironment and predict prognosis in ESCA

Objectives Pyroptosis-related genes (PRGs) are abnormally expressed in a variety of gastrointestinal tumors, this study aimed to investigate the role of pyroptosis genes in assessing the prognosis of esophageal cancer (ESCA). Methods Through consensus clustering, we identified two subtypes associate...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2023-09, Vol.149 (12), p.10701-10713
Main Authors: Shi, Youmeng, Yang, Qiuxing, Tai, Guomei, Chen, Xudong
Format: Article
Language:English
Subjects:
Apoptosis
Cancer Research
Cancer therapies
Esophageal cancer
Gene expression
Hematology
Immunotherapy
Internal Medicine
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Metastasis
Microenvironments
Oncology
Prognosis
Proteins
Pyroptosis
Radiation therapy
Software packages
Survival analysis
Tumors
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Summary:Objectives Pyroptosis-related genes (PRGs) are abnormally expressed in a variety of gastrointestinal tumors, this study aimed to investigate the role of pyroptosis genes in assessing the prognosis of esophageal cancer (ESCA). Methods Through consensus clustering, we identified two subtypes associated with PRGs. After Lasso regression and multivariate Cox regression analysis, a polygenic signature based on six prognostic PRGS was constructed. Afterwards, we combined the risk score with clinical predictors to construct and validate a PRGs-associated ESCA prognostic model. Results Through analysis, we Successfully constructed and validated a PRGs-associated ESCA prognostic model that predicts ESCA survival and correlates with the tumor immune microenvironment. Conclusion Based on PRGs features, we established a new ESCA hierarchical model. This model has important clinical implications for ESCA patients, both in terms of assessing prognosis and in terms of targeted and immunotherapy.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-023-04958-x