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Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammato...

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Bibliographic Details
Published in:World journal of clinical cases 2023-07, Vol.11 (20), p.4852-4864
Main Authors: Liu, Peng, Zhao, Ye, Rong, Dong-Dong, Li, Kai-Fu, Wang, Ya-Jun, Zhao, Jing, Kang, Hua
Format: Article
Language:English
Subjects:
Retrospective Study
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Summary:Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v11.i20.4852