Cis-platinum chemotherapy for ocular basal cell carcinoma

We have used intravenous cis-platinum chemotherapy in the treatment of three patients with basal cell carcinoma of the lid extending into the orbit. Cis-platinum chemotherapy caused a reduction in tumour size and thereby delayed surgery in all cases. It allowed for local resection in one case, appea...

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Bibliographic Details
Published in:British journal of ophthalmology 1991-07, Vol.75 (7), p.407-410
Main Authors: Morley, M., Finger, P. T., Perlin, M., Weiselberg, L. R., DeBlasio, D. S.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antineoplastic agents
Biological and medical sciences
Carcinoma, Basal Cell - diagnostic imaging
Carcinoma, Basal Cell - drug therapy
Carcinoma, Basal Cell - pathology
Chemotherapy
Cisplatin - administration & dosage
Cisplatin - therapeutic use
Eyelid Neoplasms - drug therapy
Eyelid Neoplasms - pathology
Female
Humans
Infusions, Intravenous
Male
Medical sciences
Neoplasm Invasiveness
Orbit - diagnostic imaging
Orbital Neoplasms - diagnostic imaging
Orbital Neoplasms - drug therapy
Pharmacology. Drug treatments
Tomography, X-Ray Computed
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Summary:We have used intravenous cis-platinum chemotherapy in the treatment of three patients with basal cell carcinoma of the lid extending into the orbit. Cis-platinum chemotherapy caused a reduction in tumour size and thereby delayed surgery in all cases. It allowed for local resection in one case, appeared to delay a patient's exenteration in a second case, and was used prior to radiotherapy in a third case. While not curative, cis-platinum may be useful as an adjuvant to decrease tumour mass prior to local excision and for patients who refuse or must delay exenteration.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.75.7.407