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Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning
Purpose Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to...
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| Published in: | Supportive care in cancer 2023-09, Vol.31 (9), p.521, Article 521 |
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| container_title | Supportive care in cancer |
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| creator | Oku, Saori Futatsuki, Toshiko Imamura, Yoshiko Hikita, Haruna Inada, Akemi Mizutani, Shinsuke Mori, Yasuo Kashiwazaki, Haruhiko |
| description | Purpose
Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens.
Methods
Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed. Baseline characteristics and clinical courses between the patients who received cryotherapy (cryotherapy group,
n
= 42) and those who did not (control group,
n
= 36) were compared, especially focusing on methotrexate (MTX) use as a part of graft-versus-host disease (GVHD) prophylaxis.
Results
Binary logistic regression analysis revealed that a higher dose of Mel (OR, 3.82; 95%CI, 1.085–13.46;
P
= 0.037) or MTX use (OR, 7.61; 95% CI, 2.41–23.97;
P
|
| doi_str_mv | 10.1007/s00520-023-07989-9 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10427514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A761115749</galeid><sourcerecordid>A761115749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-520a98f476e6f8c55e2fc6fb70609354c4383b7454bcf1dbe37aabda794b0d513</originalsourceid><addsrcrecordid>eNp9Uk1vFSEUJUZj69M_4MKQuHEzFQZ4DCvTNH4lTXSha8Iwl3k0MzAC0-T9lP5beb7aWmMMC-Decw6cm4PQS0rOKCHybSZEtKQhLWuIVJ1q1CN0SjljjWRMPUanRHHacCbECXqW8xUhVErRPkUnTIqOdlycopuvKRawxV8DBufqCUeHbdrHsoNklj02o_Eh13IyE55XG7MvPmMzxzBiM01xhADe4h3MpsQleij1lgvM2MI04ZJMyMtkQsEJrF88hJLxmn2lzzAtO1N7TW8yDNjGMFT1GGrzOXrizJThxe2-Qd8_vP928am5_PLx88X5ZWO5YqWpEzCqc1xuYes6KwS0zm5dL8mWKCa45axjveSC99bRoQcmjekHIxXvySAo26B3R91l7WcYbP1edaqX5GeT9joarx92gt_pMV5rSngrRZ33Br25VUjxxwq56Nnng3cTIK5Zt52glLeqFRX6-i_oVVxTqP4OKKIoV1zeo0YzgfbBxfqwPYjqc7mllApZvW_Q2T9QdQ0w-zpJcL7WHxDaI8GmmHMCd2eSEn1IlD4mStdE6V-J0gfSqz_Hc0f5HaEKYEdArq0wQrq39B_Zn7EH2qA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2850914947</pqid></control><display><type>article</type><title>Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning</title><source>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</source><source>Sociology Collection</source><source>Springer Link</source><creator>Oku, Saori ; Futatsuki, Toshiko ; Imamura, Yoshiko ; Hikita, Haruna ; Inada, Akemi ; Mizutani, Shinsuke ; Mori, Yasuo ; Kashiwazaki, Haruhiko</creator><creatorcontrib>Oku, Saori ; Futatsuki, Toshiko ; Imamura, Yoshiko ; Hikita, Haruna ; Inada, Akemi ; Mizutani, Shinsuke ; Mori, Yasuo ; Kashiwazaki, Haruhiko</creatorcontrib><description>Purpose
Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens.
Methods
Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed. Baseline characteristics and clinical courses between the patients who received cryotherapy (cryotherapy group,
n
= 42) and those who did not (control group,
n
= 36) were compared, especially focusing on methotrexate (MTX) use as a part of graft-versus-host disease (GVHD) prophylaxis.
Results
Binary logistic regression analysis revealed that a higher dose of Mel (OR, 3.82; 95%CI, 1.085–13.46;
P
= 0.037) or MTX use (OR, 7.61; 95% CI, 2.41–23.97;
P
< 0.001) was associated with the incidence of OM. MTX use was also significantly associated with the duration of OM (β = 0.515; 95% CI, 9.712–21.636;
P
< 0.001). Among 31 patients without MTX use, cryotherapy was associated with a significant reduction of OM development (0% in the cryotherapy group vs 35% in the control group,
P
= 0.021). We did not find such an association in 47 patients with MTX use.
Conclusion
Cryotherapy was useful to prevent the incidence of OM in allo-HSCT recipients in the cases without MTX for GVHD prophylaxis.</description><identifier>ISSN: 0941-4355</identifier><identifier>ISSN: 1433-7339</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-023-07989-9</identifier><identifier>PMID: 37581845</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Caspofungin ; Chemotherapy ; Comparative analysis ; Cryotherapy ; Disease prevention ; Graft versus host disease ; Hematopoietic stem cells ; Medicine ; Medicine & Public Health ; Methotrexate ; Mucositis ; Nursing ; Nursing Research ; Oncology ; Pain Medicine ; Palifermin ; Rehabilitation Medicine ; Stem cell transplantation ; Stem cells ; Stomatitis ; Transplantation ; Transplants & implants</subject><ispartof>Supportive care in cancer, 2023-09, Vol.31 (9), p.521, Article 521</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c493t-520a98f476e6f8c55e2fc6fb70609354c4383b7454bcf1dbe37aabda794b0d513</cites><orcidid>0000-0003-1512-1270</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2850914947/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2850914947?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,21394,21395,27924,27925,33611,33612,34530,34531,43733,44115,74221,74639</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37581845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oku, Saori</creatorcontrib><creatorcontrib>Futatsuki, Toshiko</creatorcontrib><creatorcontrib>Imamura, Yoshiko</creatorcontrib><creatorcontrib>Hikita, Haruna</creatorcontrib><creatorcontrib>Inada, Akemi</creatorcontrib><creatorcontrib>Mizutani, Shinsuke</creatorcontrib><creatorcontrib>Mori, Yasuo</creatorcontrib><creatorcontrib>Kashiwazaki, Haruhiko</creatorcontrib><title>Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens.
Methods
Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed. Baseline characteristics and clinical courses between the patients who received cryotherapy (cryotherapy group,
n
= 42) and those who did not (control group,
n
= 36) were compared, especially focusing on methotrexate (MTX) use as a part of graft-versus-host disease (GVHD) prophylaxis.
Results
Binary logistic regression analysis revealed that a higher dose of Mel (OR, 3.82; 95%CI, 1.085–13.46;
P
= 0.037) or MTX use (OR, 7.61; 95% CI, 2.41–23.97;
P
< 0.001) was associated with the incidence of OM. MTX use was also significantly associated with the duration of OM (β = 0.515; 95% CI, 9.712–21.636;
P
< 0.001). Among 31 patients without MTX use, cryotherapy was associated with a significant reduction of OM development (0% in the cryotherapy group vs 35% in the control group,
P
= 0.021). We did not find such an association in 47 patients with MTX use.
Conclusion
Cryotherapy was useful to prevent the incidence of OM in allo-HSCT recipients in the cases without MTX for GVHD prophylaxis.</description><subject>Cancer</subject><subject>Caspofungin</subject><subject>Chemotherapy</subject><subject>Comparative analysis</subject><subject>Cryotherapy</subject><subject>Disease prevention</subject><subject>Graft versus host disease</subject><subject>Hematopoietic stem cells</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methotrexate</subject><subject>Mucositis</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Pain Medicine</subject><subject>Palifermin</subject><subject>Rehabilitation Medicine</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stomatitis</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><issn>0941-4355</issn><issn>1433-7339</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>HEHIP</sourceid><sourceid>M2R</sourceid><sourceid>M2S</sourceid><recordid>eNp9Uk1vFSEUJUZj69M_4MKQuHEzFQZ4DCvTNH4lTXSha8Iwl3k0MzAC0-T9lP5beb7aWmMMC-Decw6cm4PQS0rOKCHybSZEtKQhLWuIVJ1q1CN0SjljjWRMPUanRHHacCbECXqW8xUhVErRPkUnTIqOdlycopuvKRawxV8DBufqCUeHbdrHsoNklj02o_Eh13IyE55XG7MvPmMzxzBiM01xhADe4h3MpsQleij1lgvM2MI04ZJMyMtkQsEJrF88hJLxmn2lzzAtO1N7TW8yDNjGMFT1GGrzOXrizJThxe2-Qd8_vP928am5_PLx88X5ZWO5YqWpEzCqc1xuYes6KwS0zm5dL8mWKCa45axjveSC99bRoQcmjekHIxXvySAo26B3R91l7WcYbP1edaqX5GeT9joarx92gt_pMV5rSngrRZ33Br25VUjxxwq56Nnng3cTIK5Zt52glLeqFRX6-i_oVVxTqP4OKKIoV1zeo0YzgfbBxfqwPYjqc7mllApZvW_Q2T9QdQ0w-zpJcL7WHxDaI8GmmHMCd2eSEn1IlD4mStdE6V-J0gfSqz_Hc0f5HaEKYEdArq0wQrq39B_Zn7EH2qA</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Oku, Saori</creator><creator>Futatsuki, Toshiko</creator><creator>Imamura, Yoshiko</creator><creator>Hikita, Haruna</creator><creator>Inada, Akemi</creator><creator>Mizutani, Shinsuke</creator><creator>Mori, Yasuo</creator><creator>Kashiwazaki, Haruhiko</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1512-1270</orcidid></search><sort><creationdate>20230901</creationdate><title>Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning</title><author>Oku, Saori ; Futatsuki, Toshiko ; Imamura, Yoshiko ; Hikita, Haruna ; Inada, Akemi ; Mizutani, Shinsuke ; Mori, Yasuo ; Kashiwazaki, Haruhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-520a98f476e6f8c55e2fc6fb70609354c4383b7454bcf1dbe37aabda794b0d513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer</topic><topic>Caspofungin</topic><topic>Chemotherapy</topic><topic>Comparative analysis</topic><topic>Cryotherapy</topic><topic>Disease prevention</topic><topic>Graft versus host disease</topic><topic>Hematopoietic stem cells</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methotrexate</topic><topic>Mucositis</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Pain Medicine</topic><topic>Palifermin</topic><topic>Rehabilitation Medicine</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Stomatitis</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oku, Saori</creatorcontrib><creatorcontrib>Futatsuki, Toshiko</creatorcontrib><creatorcontrib>Imamura, Yoshiko</creatorcontrib><creatorcontrib>Hikita, Haruna</creatorcontrib><creatorcontrib>Inada, Akemi</creatorcontrib><creatorcontrib>Mizutani, Shinsuke</creatorcontrib><creatorcontrib>Mori, Yasuo</creatorcontrib><creatorcontrib>Kashiwazaki, Haruhiko</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database (ProQuest)</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oku, Saori</au><au>Futatsuki, Toshiko</au><au>Imamura, Yoshiko</au><au>Hikita, Haruna</au><au>Inada, Akemi</au><au>Mizutani, Shinsuke</au><au>Mori, Yasuo</au><au>Kashiwazaki, Haruhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>31</volume><issue>9</issue><spage>521</spage><pages>521-</pages><artnum>521</artnum><issn>0941-4355</issn><issn>1433-7339</issn><eissn>1433-7339</eissn><abstract>Purpose
Oral cryotherapy is an effective method to prevent oral mucositis (OM) induced by chemotherapeutic agents, such as melphalan (Mel). However, there is limited data about cryotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients; thus, the current study aimed to examine the efficacy of cryotherapy among allo-HSCT recipients treated with Mel-containing regimens.
Methods
Medical records of 78 consecutive allo-HSCT recipients were retrospectively analyzed. Baseline characteristics and clinical courses between the patients who received cryotherapy (cryotherapy group,
n
= 42) and those who did not (control group,
n
= 36) were compared, especially focusing on methotrexate (MTX) use as a part of graft-versus-host disease (GVHD) prophylaxis.
Results
Binary logistic regression analysis revealed that a higher dose of Mel (OR, 3.82; 95%CI, 1.085–13.46;
P
= 0.037) or MTX use (OR, 7.61; 95% CI, 2.41–23.97;
P
< 0.001) was associated with the incidence of OM. MTX use was also significantly associated with the duration of OM (β = 0.515; 95% CI, 9.712–21.636;
P
< 0.001). Among 31 patients without MTX use, cryotherapy was associated with a significant reduction of OM development (0% in the cryotherapy group vs 35% in the control group,
P
= 0.021). We did not find such an association in 47 patients with MTX use.
Conclusion
Cryotherapy was useful to prevent the incidence of OM in allo-HSCT recipients in the cases without MTX for GVHD prophylaxis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37581845</pmid><doi>10.1007/s00520-023-07989-9</doi><orcidid>https://orcid.org/0000-0003-1512-1270</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Cancer Caspofungin Chemotherapy Comparative analysis Cryotherapy Disease prevention Graft versus host disease Hematopoietic stem cells Medicine Medicine & Public Health Methotrexate Mucositis Nursing Nursing Research Oncology Pain Medicine Palifermin Rehabilitation Medicine Stem cell transplantation Stem cells Stomatitis Transplantation Transplants & implants |
| title | Protective effect of cryotherapy against oral mucositis among allogeneic hematopoietic stem cell transplant recipients using melphalan-based conditioning |
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