sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity

Expression of human tau in neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene protects against progressive motor uncoordination and neurodegeneration in models of tauopathy...

Full description

Saved in:
Bibliographic Details
Published in:microPublication biology 2023, Vol.2023
Main Authors: Currey, Heather N, Kraemer, Brian C, Liachko, Nicole F
Format: Article
Language:English
Subjects:
C. Elegans
Findings Previously Not Shown
Models of Human Disease
New Finding
Phenotype Data
Successful
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Expression of human tau in neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene protects against progressive motor uncoordination and neurodegeneration in models of tauopathy. To determine whether LOF also protects against shortened lifespan of tau transgenic , we conducted lifespan assays comparing four different alleles of We found that LOF robustly suppresses the shortened lifespan of tau transgenic animals. We also demonstrate that tau transgenic exhibit hyperactive pharyngeal pumping, which is restored by LOF.
ISSN:2578-9430
2578-9430
DOI:10.17912/micropub.biology.000844