Immunological investigations in post-traumatic granulomatous and non-granulomatous uveitis

Histopathological and immunological investigations have been performed in 16 cases of post-traumatic granulomatous (10) and non-granulomatous uveitis (6). Most cases of sympathetic ophthalmitis showed evidence of cell mediated immunity to uveoretinal antigens, though it was not possible to make a de...

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Bibliographic Details
Published in:British journal of ophthalmology 1978-10, Vol.62 (10), p.722-728
Main Authors: Rahi, A, Morgan, G, Levy, I, Dinning, W
Format: Article
Language:English
Subjects:
Antigens
Autoantibodies - analysis
Eye Injuries - complications
Granuloma - etiology
Granuloma - immunology
Humans
Immunity, Cellular
Immunoglobulins - analysis
Ophthalmia, Sympathetic - immunology
Retina - immunology
Uvea - immunology
Uveitis - etiology
Uveitis - immunology
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Summary:Histopathological and immunological investigations have been performed in 16 cases of post-traumatic granulomatous (10) and non-granulomatous uveitis (6). Most cases of sympathetic ophthalmitis showed evidence of cell mediated immunity to uveoretinal antigens, though it was not possible to make a definitive diagnosis on immunological grounds alone. Three patients with post-traumatic non-granulomatous uveitis showed a positive immunological response to ocular antigens, and 2 of these later developed clinical evidence of sympathetic ophthalmitis, which suggests that post-traumatic non-granulomatous uveitis in such cases may represent a presympathetic (i.e., incipient) or modified stage of the disease.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.62.10.722