Experimental retinal branch vein occlusion in rhesus monkeys. III. Histopathological and electron microscopical studies

Experimental retinal vein occlusion in monkeys was followed by an immediate increase in capillary permeability which was accompanied by retinal oedema. This functional capillary change was followed at about 6 hours after occlusion by structural damage to the capillary wall. Thrombus formation occurr...

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Bibliographic Details
Published in:British journal of ophthalmology 1979-06, Vol.63 (6), p.393-411
Main Authors: Hockley, D J, Tripathi, R C, Ashton, N
Format: Article
Language:English
Subjects:
Animals
Capillaries - ultrastructure
Capillary Permeability
Constriction, Pathologic
Edema - etiology
Edema - pathology
Haplorhini
Macaca mulatta
Microscopy, Electron
Retina - ultrastructure
Retinal Diseases - etiology
Retinal Diseases - pathology
Retinal Hemorrhage - etiology
Retinal Hemorrhage - pathology
Retinal Vein - ultrastructure
Time Factors
Vascular Diseases - pathology
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Summary:Experimental retinal vein occlusion in monkeys was followed by an immediate increase in capillary permeability which was accompanied by retinal oedema. This functional capillary change was followed at about 6 hours after occlusion by structural damage to the capillary wall. Thrombus formation occurred in the damaged vessels, and areas of stasis were thus produced with associated retinal haemorrhages. Finally, there was complete loss of the capillary endothelium and pericytes, and the acellular capillaries were invaded by proliferating glial cell processes, so producing permanent capillary closure.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.63.6.393