A Case Report of Kearns-Sayre Syndrome: Not an Absolute Contraindication for Radiotherapy

Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such a population group are unknown. A 60-year-old male with a history of KSS was diagnosed with locally advanced basal cell carcinoma along the left inner canthus. He was treated at our institution with...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-07, Vol.15 (7)
Main Authors: Yap, Shaun Z, Mohd Tahir, Abdul Rahim, Shakespeare, Thomas P
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Case reports
Contraindications
Dermatitis
Exocrine glands
Genetics
Medical imaging
Mitochondrial DNA
Pacemakers
Radiation Oncology
Radiation therapy
Skin cancer
Squamous cell carcinoma
Tomography
Toxicity
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Summary:Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such a population group are unknown. A 60-year-old male with a history of KSS was diagnosed with locally advanced basal cell carcinoma along the left inner canthus. He was treated at our institution with curative intent radiotherapy alone and tolerated it well with no major acute or late toxicities. There was a complete clinical and radiological response of the tumor, with no evidence of recurrence 2.5 years after treatment. Further research is needed to explore the effects of ionizing radiation on patients with mitochondrial DNA defects.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.42229